I've been on 5FU and leucovorin for 5 months now, and since February the corners of my mouth have been split and inflamed. I've treid every type of chapstick and lip balm, but no success.
This week, I had lunch with a dermatologist friend, and she was concerned about my mouth; said that often there is a little infection (either bacterial or fungal) and wrote me a scrip for Mycalog ointment....well, 3 days later, the cracks are healed....no more splitting open every time I try to eat something!! It's been a minor but constant painful annoyance for months. So...if anyone else has the same problem consider my experience. My onc says he's never prescribed mycalog for anyone....hope that changes.