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T2C NX MO What is PIN?

Posts: 24
Joined: Apr 2003

Hi again to all,

Bob's prostate cancer is staged as T2C NX MO

Think I have that part figured out but what is PIN? The oncologist's letter reads "no perineural invasion and there was evidence of high grade PIN".

Bob will go to the oncologist tomorrow. They are recommending hormone treatments for 4 months and then 39 treatments of radiation (total dose of 7020 cGy).

I'm not sure what Bob is going to do. They say watchful waiting is not a good option for him.

Thanks for your help in advance. This is a terrific site.

All the best, Karlen

2ndBase's picture
Posts: 220
Joined: Mar 2004

I had the same stage diagnosed in Nov.02 and took one shot of Lupron followed by 40 rad. treatments which ended one year ago. Im not convinced it was a good idea to get treated this way as I can no longer work and now have no insurance. The doctors tried to scare me with comments like if I did not get treated I might as well commit suicide. The treatments are life changing and not guaranteed to help. If Bob wants to talk let me know. Best wishes.

Posts: 117
Joined: May 2003

Hi Karlen,
PIN is a measure of pre-cancerous cells and the level of 70 Gray is typical.No Perineural invasion is a good sign because otherwise the nerves are "pipelines".
I concur that "watchful waiting" is no option at all!
Good luck,Benji

Posts: 117
Joined: May 2003

Hi again Karlen,
Here's an article on PIN:
Prostatic intraepithelial neoplasia (PIN) is a condition in which there are changes in the microscopic appearance (the size, shape, or the rate at which they multiply) of prostate epithelial cells. Older men are more likely to have this condition. PIN is classified as either low grade or high grade. If a person has high grade PIN, repeat biopsies and PSA tests should be done regularly. PIN may lead to the development of prostate cancer. At this time there is no standard treatment for PIN. Studies are being done to determine if treatments used for BPH (benign prostatic hyperplasia) are also effective in treating PIN.

The key word is "MAY" lead to prostate cancer.

If you want more info by any chance go to Google and plug in "PIN cancer cells" & you'll get many hits. I don't know how useful it'll be however.

Posts: 232
Joined: May 2003

Hi,My husband had Lupron while he was in radiation and one shot right after he finished, three months in all. He had a PSA of 60. He had external radiation with 28 full pelvic and 16 IMRT. It has been one year nearly since he finished treatment. He has worked everyday and feels fine. He did hate the Lupron and says never again and did quit much sooner then the Drs wanted. He is on a great many herbs and vitamins and a vegan diet. Check out diet and prostate cancer there is a lot to learn on this issue. Many studies are being done with surprising results showing up. Good luck, our life has not changed much dispite the cancer, maybe we love life a bit more and say thanks a lot more. Linda