Her2+ study

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chemoqueen1
chemoqueen1 Member Posts: 50
edited March 2014 in Breast Cancer #1
I have seen serveral postings from people who are Her2+ and have some information about an ongoing study through the US Oncology group that may be helpful to those who are Node Neg with Her2+ tumor. The folowing web sites may be helpful


http://www.bcirg.org/Internet/Studies/BCIRG+006.htm

http://www.gene.com/gene/pipeline/trials/herceptin/bcirg006/index.jsp

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  • rainyday
    rainyday Member Posts: 49
    #2
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    Thanks Chemoqueen. I am HER2/neu 2+ and would have to have the FISH test to confirm whether it really is a + and whether it really indicates ampplification of the oncogene. In various studies the 2+ false positives have ranged from 32% to as high as 76% and hence those tumors shouldn't be treated with herceptin. I have been asking my onc. for the FISH test for the past week and will insist on it Monday. That said it takes time and it is more expensive. I am confused. Supposedly Tamoxafen is not considered to be effective if you are HER2+ but what happens when you are both highly ER/PR + but you are also HER2 +?
  • JKAlley
    JKAlley Member Posts: 84
    #3
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    rainyday said:

    Thanks Chemoqueen. I am HER2/neu 2+ and would have to have the FISH test to confirm whether it really is a + and whether it really indicates ampplification of the oncogene. In various studies the 2+ false positives have ranged from 32% to as high as 76% and hence those tumors shouldn't be treated with herceptin. I have been asking my onc. for the FISH test for the past week and will insist on it Monday. That said it takes time and it is more expensive. I am confused. Supposedly Tamoxafen is not considered to be effective if you are HER2+ but what happens when you are both highly ER/PR + but you are also HER2 +?

    Thanks Chemoqueen. I'm her2neu 3+, node pos, got in to a clinical trial for herceptin. Had ac 1 every 3 wks x 4, and now I start taxol and herceptin once a wk x 12, will continue on herceptin for 52 wks. I really dread radiation and herceptin at the same time! My tumor was invasive at 2.2 cm, so I know I have to get the most aggresive treatment I can, and this seems to be it. I'm trying to find as much as I can about this trial (swog 9831), and any others. Positive thoughts to all.
  • JKAlley
    JKAlley Member Posts: 84
    #4
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    JKAlley said:

    Thanks Chemoqueen. I'm her2neu 3+, node pos, got in to a clinical trial for herceptin. Had ac 1 every 3 wks x 4, and now I start taxol and herceptin once a wk x 12, will continue on herceptin for 52 wks. I really dread radiation and herceptin at the same time! My tumor was invasive at 2.2 cm, so I know I have to get the most aggresive treatment I can, and this seems to be it. I'm trying to find as much as I can about this trial (swog 9831), and any others. Positive thoughts to all.

    Oh yea, I'm also er/pr neg. I don't know if that makes any difference in this study or not. Thanks again, chemoqueen.
  • chemoqueen1
    chemoqueen1 Member Posts: 50
    #5
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    rainyday said:

    Thanks Chemoqueen. I am HER2/neu 2+ and would have to have the FISH test to confirm whether it really is a + and whether it really indicates ampplification of the oncogene. In various studies the 2+ false positives have ranged from 32% to as high as 76% and hence those tumors shouldn't be treated with herceptin. I have been asking my onc. for the FISH test for the past week and will insist on it Monday. That said it takes time and it is more expensive. I am confused. Supposedly Tamoxafen is not considered to be effective if you are HER2+ but what happens when you are both highly ER/PR + but you are also HER2 +?

    Rainyday, I was also ER/PR + I will go on tamoxifen once i finish with the Herceptine (52 weeks after my last Taxotere/Cyboplatin) The ER/PR status does not have a bearing on being in the trial.

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