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Ovarian Cancer New Therapy Appraoch

Despite billions of dollars spent over the past decades on research, ovarian cancer still has high mortality rates. This indicates that scientists need a new and better approach to fight it by targeting its initiation through the stem cells, Cancer Stem Cells (CSCs).

Cancer stem cells (CSCs) are malignant cells within a tumor that have self-renewal characteristics similar to normal stem cells but lead toformation of cancerous tumor. According to a recent research, scientists have found that attacking CSCs can be the best way to overcome ovarian cancer.

The reason is because epithelial ovarian cancers (EOC) are account for nearly 90% of all ovarian cancer cases and are thought to arise from ovarian surface epithelium stem cells or fallopian tube epithelium. This leads the researchers to focus on EOC in the majority of ovarian CSC studies.

CSCs are capable of generating primary and recurrent ovarian cancer through extensive rounds of asymmetric division; therefore, a scientific approach to combat it by attacking the root of the problem deserves favorable consideration.

Ovarian cancer silently and progressively develops toward an advanced condition. Although it is often successfully treated with a combination of surgery and chemotherapy, the tumor tends to turn into terminal, recurrent, or chemoresistant in high percentage of patients. This new approach brings more hope that there will be a better prognosis for the disease.

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References:

Jung, M. J.,et al. Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene. 32, 209–221 (2013).

Lengyel E: Ovarian cancer development and metastasis.

Am J Pathol 2010, 177:1053-1064. PubMed Abstract | Publisher Full Text | PubMed Central Full Text

Molecular Cancer 2014, 13:262  doi:10.1186/1476-4598-13-262

David Wolfe and Shazzie (2005). Naked Chocolate: The Astonishing Truth about the World’s Greatest Food. North Atlantic Books. p. 98. ISBN 1-55643-731-5. Retrieved 15 December 2011.

Humphrey Hawksley (12 April 2001). “Mali’s children in chocolate slavery”. BBC cancer News. Cancer prevention.  Retrieved 2 January 2010.

Humphrey Hawksley (4 May 2001). “Ivory Coast accuses chocolate companies”. BBC News. Retrieved 4 August 2010.

U.S. Department of State Country Reports on Human Rights Practices, 2005 Human Rights Report on Côte d’Ivoire

ilo.law.cornell.edu: Chocolate and cancer

 

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