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Avastin and Xeloda

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

Well my oncologist is stopping the Avastin, Irinotecan and  5-fu because of low WBC. He's ordered Avastin and Xeloda. I'm not sure how long i will be taking this stuff. Probably the full 12 treatments.

Has anyone been on this combination? I was on Xeloda pills and Oxiliplatin previously. I tolerated it ok. I only had a few delays in treatment because of WBC while on that. I had a little neuropathy that remains in my feet. The only problem was taking a boat load of huge pills (Xeloda). It got very very hard towards the end and I would sometimes forget to take them at the right time. I think I would rather get the Xeloda via pump this time.

k

Betsydoglover's picture
Betsydoglover
Posts: 1254
Joined: Jul 2005

I was on this combo twice - the 1st in 2005 was also with oxaliplatin.  In 2009 I had Xeloda and Avastin, followed by Avastin only for up to 2 years (Stage 4).

As far as I could tell, I had no Avastin side effects other than nasal congestion (which sucked, but as side effects go was pretty mild.).

As for the Xeloda pills, yes they are huge, and even though it's been 9 years since I had one, I can still smell / taste that slightly smokiness (to me).  To not forget, I would eat breakfast and then as soon as done set the timer for 20 minutes.  Then I took the pills.  Same for dinner.  Also I used a lot of water to wash them down - that helped.

Take care,

Betsy

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

What a good idea! I will definitely do that. 
I must say, it's wonderful that the first response is from someone who's been NED for so long. I hope that I can get the same response!

thanks

k

abita's picture
abita
Posts: 608
Joined: Dec 2017

That is interesting. My post chemo scan showed spots that my doctor thinks are cancer. He went on vacation, so I have a nice long 3 weeks to ponder before I find out what treatment and such (depends on what the pet ct scan shows). I have considered how I will handle all the various treatments since I don't know what I will get. When I considered 5fu, I was thinking, "no pump, this time I want the pills!!!!!" I guess grass is always greener

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

Yea, the pills sounded so much better to me the first round of chemo but they were hard to manage. You have to take them at exactly 12 hours after the last time. I would be busy with whatever and totally forget to take them until later. You really need to take them after you eat so that you stomach can handle it.

I don't know. I was on the pump these past 3 treatments. It was 5-FU/Avastin/Irintecan. While the side effects of the chemo were rough, the pump didn't really bother me that much.

Like you said, the grass is always greener.

k

 

mountainhiker
Posts: 54
Joined: Aug 2018

Never had Avastin or Xeloda, however I can relate to your boatload of pills problem.  About 2 months into chemo I contracted Nocardia bacteria and was on IV antibiotics for 3 straight months.  Needle and tubing hanging out of my port 24/7.  I would pull the needle on Tuesday nights and the nurse would stop by 6am Wednesday to plug me back in so I'd be good for another week.  When the dr said there was a possibility of switching me over to oral antibiotics I jumped at the chance.  She was concerned that I wouldn't want to do it since I would be taking a bunch of pills each day for the next 9 months.  I told her I would take a whole bottle full of pills everyday if it meant getting unplugged from that IV line.

mountainhiker

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

Yea, pills would definitely be better than that situation. I hope you are doing better now.

k

 

Ruthmomto4's picture
Ruthmomto4
Posts: 636
Joined: May 2013

took avastin only side effect was small jump in his blood pressure. They put him on hydorchlorathiazide (water pill basically) he was fine. He could not tolerate irinotecan only got one dose before it gave him pancreatitis. Good luck! 

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

I've never had a problem with my blood pressure until recently. I think the chemo drove it up. I will ask the doc about this med.

thanks so much

k

abita's picture
abita
Posts: 608
Joined: Dec 2017

On infusion day, my blood pressure would be something like 150 over 90 something. Two days later on disconnect from pump day, it would be normal. I was always so happy on disconnect day! Exhausted, but happy

Tunadog's picture
Tunadog
Posts: 232
Joined: Mar 2017

Infused with Avastin and then Xeloda pills. My Cancer is about gone, butt I have a nasty infection. My Rectal Surgeon told me that sometimes an infection is harder to deal with than cancer.

It sent me to the hospital. My WBC got low and I an getting Antibiotics now. It's about cleared up now. I have a tube draining my rectum to a bag. So the infection is on the wane. They indicated that l was going Septic (almost).

Looking for relief 

abita's picture
abita
Posts: 608
Joined: Dec 2017

Was that from the drugs or because more susceptible with chemo?

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

I hope you recover soon. Thanks for the info.

K

plsletitrain
Posts: 253
Joined: Jul 2017

I had avastin twice and had it in combo with xeloda (without the oxaliplatin).  Its at this time that the blistered/dry feet came upon, so I'm not sure which one's the culprit. I'm guessing its the xeloda.  I think the worse side effect of xeloda is the irregular heartbeats I've experienced.  Another is I think the oxaliplatin is set to a higher dose when it is paired with the xeloda so on infusion day, I felt weaker than when I had the 5Fu.  In response to your post on the other thread, I think my doctor would want me to do 12 treatments but he knows I'm stubborn (I didn't complete my previous treatments, some schedules I missed, etc. for various reasons) so he knows I may not be amenable to a 12-course treatment so he just told me, at least do 6.

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

If I recall I didn't have any skin problems with the Xeloda. Hoping I do as well this time.

Thanks

K

Annabelle41415's picture
Annabelle41415
Posts: 6185
Joined: Feb 2009

Hated taking the pills because you need to take them with food and I'm not a breakfast person and forced myself to eat.  Had to really figure out when to eat even though really not wanting too.  They were big and didn't like looking at how many that were layed out for the day because they didn't go down well for me.  I've not done the Avastin.  Wishing you well on this new combination.

Kim

Trubrit's picture
Trubrit
Posts: 4831
Joined: Jan 2013

I was hooked up to the pump (5FU) for six weeks straight, and it was way easier than I had imagined. The only problem I had, was the pump quit one night.  

Yeah, I'm a big pump advocate.

Tru

Annabelle41415's picture
Annabelle41415
Posts: 6185
Joined: Feb 2009

Pump for 6 weeks - that would be hard.  It was hard for me to sleep, take a shower, move with that.  Never had mine quit but it did run out before it was supposed to.  Must have gotten too much at one time.  The pump was only 3 days for me every other week.  That was after Xeloda pill though.  That was during my actual hard chemo and at the same time to go home with.  You've been through alot Tru.

Kim

Trubrit's picture
Trubrit
Posts: 4831
Joined: Jan 2013

I hated the pump for 48 hours, and knowing I would be hooked up to it 24/7 filled me with dread.  BUT, it ended up being much better than the 48 hour deal.  

I think I was just so desperate to get that thing removed and knowing that it was going to be removed on day 2, that I ended up hating it. When I knew that it was there for the duration, well, it just became a part of me and much easier to accept.

I would recommend it over the pills; but then, I hate taking pills. Even my teeny weeny Synthroid tablet makes me gag, and I've been taking it 20 years. 

Tru

Kazenmax's picture
Kazenmax
Posts: 350
Joined: Feb 2016

Doctor told me that the only option was the pills. Ugh. Not sure what the dosage is yet. 

K

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