Wouldn't it be lovely (Chrysin)

SandiaBuddy
SandiaBuddy Member Posts: 1,299 Member
edited June 2018 in Colorectal Cancer #1

This is a test-tube study from Taiwan of a botanical chrysin (available for sale now in specialtly stores) that they theorize could be as effective as oxaliplatin/5FU.  Of course, this is preliminary information, but wouldn't it be lovely if it panned out?

http://www.mdpi.com/1422-0067/19/6/1763/htm

Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin.

* * *

We found that chrysin exhibited similar inhibition of cell viability as the 5-FU combination in a panel of human CRC cells. Furthermore, the results showed that chrysin significantly increased the levels of LC3-II, an autophagy-related marker, in CRC cells, which was not observed with the 5-FU combination. More importantly, blockage of autophagy induction restored chrysin-attenuated CRC cell viability. Further mechanistic analysis revealed that chrysin, not the 5-FU combination, induced ROS generation, and in turn, inhibited the phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR). Collectively, these results imply that chrysin may be a potential replacement for the 5-FU and oxaliplatin combination to achieve antitumor activity through autophagy for CRC treatment in the future.

Comments

  • JanJan63
    JanJan63 Member Posts: 2,478 Member
    Thanks for sharing that!

    Thanks for sharing that! There's got to be some sort of breakthorugh coming soon. Maybe this is it!

    Jan

  • BRHMichigan
    BRHMichigan Member Posts: 368
    edited June 2018 #3
    Great stuff

    Hadn't heard of this before. Thanks for sharing. 

  • Annabelle41415
    Annabelle41415 Member Posts: 6,728 Member
    Wow

    That would be great.  5FU has so many side effects so if this one didn't it would be great.

    Kim

  • myAZmountain
    myAZmountain Member Posts: 417 Member
    Great articles

    Lying here 3 days post Folfox the idea of a kindler gentler chemo sounds fabulous! Appreciate this articel and also the one regarding lung mets. There is such hope on the Horizon!

  • steveja
    steveja Member Posts: 41
    Don't get your hopes too high

    That study was "in vitro" they tested against CRC cells in a lab culture.  The study notes that it may be hard to apply chrysin to animals & humans as the molecule is rapidly eliminated.  The molecule will need to be modified & testing in lab animals, then humans.  Long way off.

     

  • BGNor
    BGNor Member Posts: 30
    edited June 2018 #7
    Thanks for the interesting

    Thanks for the interesting links.

    Here's another one along the same line. It's a university study, so quite interesting:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985046/pdf/apjtb-04-05-337.pdf

     

    Another interesting one (something you may want to read a bit more critically, but still interesting):

    https://www.beenefits.com/propolis-and-cancer.pdf

     

    Cheers, BG

  • darcher
    darcher Member Posts: 304 Member
    Direct application

     to the tumor Is what I'm thinking.   Since most of the tumors can be gotten to the same way they're discovered there is no real reason that it can't be done.

  • peterz54
    peterz54 Member Posts: 341
    Thanks for post

    On mTOR which was mentioned in the study -

    I've noticed that mTOR ( mammalian target of rapamycin) comes up over and over again in aging studies as well as cancer.   Too much cell signialing from the mTOR complex is apprently not good for aging or some forms of cancer.

    One stimultor of mTOR is insulin.   Insulin, in turn, is regulated, in part, by glucose and protein (don't want too much of either).  Which, apparently, is why some forms of short term fasting and dietary restriction seem to help with some types of cancer.   And why I am still puzzled that oncologists aren't more careful about insulin and glucose control in their patients, especially around each treatment session.   Speculation, but one of the benefits of excercise may be the mTOR lowering effects by way of lowering glucose and insulin.

    Also, there seem to be several other natural substances which can inhibit mTOR a bit.  Partial list from my notes:  EGCG (green tea), curcumin, (tumeric), caffiene, resveratrol, quercetin (onions, apples).  Also, one of several studies - 

     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775843/pdf/nihms-512572.pdf