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PolyPEPI1018 trial (cancer vaccine)

Mikenh's picture
Mikenh
Posts: 670
Joined: Oct 2017

This is an immunotherapy trial for Tumor Infiltrating Lymphocytes targetting common CRC cancer genes. My guess is that this is follow-on work from NCI. This could be incredibly exciting stuff as this could cure common KRAS mutations in CRC. My guess is that it could cure other types of cancer as well with these mutations. I'm guessing the G12D and G12V are covered. I think that six mutations are covered overall and I don't know which the others would be.

 

https://clinicaltrials.gov/ct2/show/NCT03391232

Mikenh's picture
Mikenh
Posts: 670
Joined: Oct 2017

There's another similar vaccine in trials in South Korea.

darcher's picture
darcher
Posts: 202
Joined: Jun 2017

  A cancer vaccine would have been great to have a few years back before this mess started.  If it's a cure and doesn't do the damage chemo and radiation does it's worth it's weight in gold.

Mikenh's picture
Mikenh
Posts: 670
Joined: Oct 2017

I think that these vaccines are fairly narrow in the gene mutations that they target but I think that they target the most common ones.

kyolcu
Posts: 62
Joined: Jun 2017

Thanks for postings. Has anyone heard about vaccine in Israel. I read it somewhere but I don’t have updated information. Please let us know, if you guys heard anything about it. I believe they started trials in human this year.

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