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Transdermal Estrogen vs Lupron; a matter in the Quality of Life

VascodaGama's picture
VascodaGama
Posts: 2929
Joined: Nov 2010

 

Today I waken up to the news that Britain managed to unchain its locks in the EU. Congratulations to all the Brits. However, bigger news came on my email with a video from Dr. Myers. This is about Estrogens substituting Lupron in hormonal treatments. This is a matter we survivors in this forum so many times have discussed and that now is verified by the Hero of PCa oncology.

Here is the information that many comrades suffering from Lupron’s side effects will be delighted in knowing;

https://askdrmyers.wordpress.com/2016/06/22/transdermal-estrogen-versus-lupron/?ct=t(Transdermal_Estrogen_Versus_Lupron_June_6_20_2016)&mc_cid=dcf5ce1d86&mc_eid=179dca884e

I am ready to provide opinions on the matter and would like to receive your opinions if any.

For the moment enjoy the video.

VGama

 

Old Salt
Posts: 720
Joined: Aug 2014

I know that Dr Myers is highly thought of, but at the very least, I would like to see (table or graph) the lowering of the testosterone after application of the estrogen patches.

bob33462
Posts: 78
Joined: Feb 2016

VGama -

Thank you, I watched the clip. Appears like the Estrogens are not for eveyone and not sure how cancer growth supression results stack up against Lupron. I know, from what Dr. Myers said, the SE's are less on Estrogens.

I'm not sure the Brit's made a good choice - per my Barron's yesterday, their GDP will be impaired. Also, contagion may set in with other member counties to pull out, possibly causing a world wide recession.

But, the voters have spoken and there is not a very good chance the vote will be recinded with a we made a mistake vote.

Bobby Mac

 

 

 

 

VascodaGama's picture
VascodaGama
Posts: 2929
Joined: Nov 2010

Thanks guys for the opinions.

Old Salt; I have no tables or graphs regarding the comparison in castration inducing drugs, but there is a trial running since 2006 to verify the effectiveness of estrogen patches against LHRH injections, which interim reports may be the basis today at the hands of oncologists to prefer to treat patients with the patches, because these seem to get the results done similarly to LHRH agonists (T< 50 ng/dL) with lesser side effects.
In fact we know that estrogens have been in use for many years to “treat” the menopause symptoms (the ones affecting most of our comrades). A drug abolished in the US but still used by many is the infamous DES Diethylstilbestrol made of similar bio structure. Also, in 2003 one small trial was done to compare symptoms caused by pills against patches in a cohort of 20 PCa patients. They found the Transdermal Estradiol to be effective against cancer with lesser cardiovascular toxicity than the pills. (http://www.ncbi.nlm.nih.gov/pubmed/12686820)

 Here is an old link to the trial with the details;
http://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-looking-at-hormone-patches-for-prostate-cancer#undefined

An abstract of the results is here;
http://www.cancernetwork.com/prostate-cancer/estrogen-patch-treats-prostate-cancer-fewer-adverse-events

Dr. Myers recommends Estradiol patches in some of his ADT patients so that he may know as a fact on the benefits, however, USA clinical trials also have hold several trials on the patches which data may have contributed to his and other oncologists assertions. Here is one started in 2005;
https://clinicaltrials.gov/ct2/show/NCT00176644

I became curious about Estradiol since reading an article written by my “Guard Angel” Mrs. Jacqueline Strax, back in 2005. She plotted percentages in symptoms and wrote the assertion from an oncologist that “…Patients with prostate cancer treated with androgen suppression are at risk for skeletal fracture and the risk increases with the duration of the therapy”.
Please note that I am just a patient so that all my opinions are based on references I read on the matter.

Bob; Both, Estradiol and Lupron act in cancer growth suppression by cleaning our system off Testosterone.They do not kill the cancer but prolong its laziness (indolence) till it finds a way of survival (living on tiny substances of androgens produced by itself) causing refractory to the drugs. I think that you would do well in knowing your circulating testosterone level now to compare it with latter  test results done after starting Lupron.

Regarding British’s EU membership, I think it impossible for them to accept EU regulations (produced by 28 countries). They could negotiate for exceptions but if granted then EU main principles would become into jeopardy. Free trade, free circulation of people and free access to the social basics (education, health and employment) in all member countries. These are the problems in the EU because we have approximately 350 million of citizens looking for that at the best serviced countries. Now still worse with the immigrates affairs from Africa and the Middle East, looking for the same opportunity. Nobody wants them and nobody wants to build a newer Berlin-wall. Human rights are in the agenda and that cannot be assumed or tottaly acepted by everybody. The Brits chose well. Now they need to negotiate a way of continuing as a partner of the EU in terms of trade as they used to be when the EU was the EEC (European Economic Community). https://en.wikipedia.org/wiki/European_Economic_Community

In my view the EU will be more affected by Britain’s withdrawing. The Pound will also do better than the Euro for its group of permanent supporters such as Australia, Canada, New Zealand and Arabic friends. Europeans from the rest 27 countries will also benefit because the situation has stricken the EU regulators in Brussels to change. They surely will modify its views regarding the norms in social affairs placing it above the present economic regulations. Not doing it they will risk more members to leave the Union.

Best wishes,

VGama

 

bob33462
Posts: 78
Joined: Feb 2016

Thanks for the additional information on estrogens.

I do understand the Brits frustration with the regulations - time will tell if it was a good move.

Right now it causing increased world stock market market volatility and the pound is taking a dive..

Bobby Mac

 

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