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Myrbetriq

daytona19
Posts: 54
Joined: Sep 2014

Hi Panel,

Anyone using Myrbetriq and how ie the results? I used it and it did well and i can not start on it again till I get over my surgery.

daytona19

VascodaGama's picture
VascodaGama
Posts: 2969
Joined: Nov 2010

Daytona

I am curious when reading your posts. You did oligometastases treatment and got urinary urgency which issues may relate to me and my future treatment steps. I am very interested in knowing facts and about your experiences.

http://csn.cancer.org/node/296402#comment-1512643

In your last thread you commented about Myrbetriq (mirabegron) for the OAB issue. This is also an issue to me. However, I have postponed to take the drug because of its possible interaction with the HT drugs that I will have to take in my continuing PCa treatment. Unfortunately or most fortunate my consultation regarding the PCa has been postponed by my doctor. My PSA is yet under the threshold mark (PSA=2.0 ng/ml) to restart ADT, but the situation makes it difficult to define a date to start mirabegron.

I have no experience to tell you something of interest about Myrbetriq but from researches, I found that this drug acts differently than other traditional anticholinergics and antispasmodics medicines used in the treatment of temporary urge incontinence cases or even in nasty cases of incontinence.
Mirabegron works by relaxing the detrusor muscle in the wall of the bladder. It is a norepinephrine agonist so that it stops urgency symptom pass ways (beta 3 receptors) in the bladder walls. In any case it did not work well in all patients. In some it has caused permanent retention of urine turning the treatment into a nightmare. In others it did not function so effectively. It is also not recommended in patients taking drugs for hypertension or in severe uncontrolled hypertensive patients.

I am glad to know that this drug worked effectively in your case. I wonder why you have been recommended to stop Myrbetriq. Is it because of your continuing HT treatment?
You say surgery but what kind of surgery are you expecting to perform?

There is a warning comment at the drugs site saying this:

You should not stop taking this medicine if you do not notice an improvement in your symptoms straightaway. It may take some time for your bladder to adapt and your symptoms to improve. You should continue with the tablets and only stop taking them if you have discussed it with your doctor, because if you stop treatment your overactive bladder symptoms may come back.”

Best wishes in your continuing treatment.

VGama

daytona19
Posts: 54
Joined: Sep 2014

Hi V Gama

As you know from my postings Dr. Bavo found 8 lymph nodes that had cancer spots so the 50 radiation sessions were for that. The whole time I going through that i took the myrbetriq and it worked great.

Dr. Dattoli noticed on my last several tests and the one that Dr. Bavo did that I had a spot in my prostate bed that he said was cancer. He felt a nodule there. on Sept. 17 I went to the hospital and he put seeds into it. I spent the night in the hospital and when I got out because of the swelling and the cathater my urgr incontinence was near uncontrolable. Dattili because of the seeds wanted to make sure I drink plenty of water to make sure to irrigate the area so he put me on flowmax. my incontinence has gotten better but still not great.

I have requested to start the myrbetriq in the next few weeks.

Dr. Dattoli wants me to stay on HT for a year and see if we can get pca under control. HT also causes urge incontinence.

I will keep you informed how it goes and hope that it helps you in your battle.

daytona19 

daytona19
Posts: 54
Joined: Sep 2014

ddar V G and panel,

Went to Dr.Dattoli for testing. Had the color-flow doppler ultrasound, helical CT pelvis, adomen and chest and the QCT for bone density.

The tests didn't show anything of concern. After June 1 he wants me to stop the bicalutamide and trelstar and keep on the finasteride,cabergoline, metformin and estradiol patch.  still take myrbetriq and it seems to help but after all that radiation i still use 3 pads a day.My testerone is 20 and I go to the gym 5 days a week and started playing golf once a week.

I will keep taking the prolia shot every 6 months and take enough vitamins to keep the drug store in business.

Hope everyone is doing well and the battle goes on it has been 11 years since my operation.

daytona19

VascodaGama's picture
VascodaGama
Posts: 2969
Joined: Nov 2010

Daytona

I am glad to know about the results of the tests, exams and treatment progress. Two months after stopping Trestar you will start experiencing still more improvements in regards to fatigue and incontinence. Once the testosterone increases you may stop using the estradiol patches.

I want to thank you for sharing the events of your treatment as them may "apply" to me in the future. I wonder why you taking Cabergoline? This is a drug used to avoid production of the hormone prolactine (breast milk), which test I did recently, by orders of my GP. The levels were OK but do not understand what is the relationship between prolactin and prostate cancer or its treatment. Does prostate cancer feed on prolactin too? I am confused. This drug action is at the pituitary, and some guys take it to have faster orgasms.

I do understand the role of metformin in your protocol of medications, taken to avoid diabetes (type 2). HT can lead to diabetes. What about the vitamins recommended by your doctor. Can you list it up?

Best wishes for continuing improvements.

Enjoy.

VG

 

  

daytona19
Posts: 54
Joined: Sep 2014

Hi V G

The Cabergoline acts to suppress prolactin levels.Not sure why I need that but Dattoli thinks so. The vitamins he has me taking are 600mg of calcium, 5,000 of d3 and I take b-12 and magnesium as it seems to help my energy. I get a Prolia shot every 6 months. Saw a show on tv that has metformin as a wonder drug for aging people it has anti-tumor properties and since sugar feeds PCA it helps take it out of your body. In fact I cut way back on sugar and it seems to help my incontinence, gone from 4 pads to 2.I know there is cancer somewhere in my body but I am glad for now it is under control.As Dattoli said he wants to make it a chronic illness not a fatal one.

daytona19

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