Serous papillary endometrial adenocarcinoma vs other uterine cancers

Lou Ann, a few years ago I

Lou Ann, a few years ago I took a very good (free too) course given by the Foundation for Women's Cancer that was specific for Uterine cancers.  Type 1 are typically "typical garden variety" types that can be treated with surgery and no additional treatment is needed. The Type II cancers are a subset and more agressive.  They include the UPSC and a few others, and then there is the MMMT that is very agressive and is considered outside these two types. 

I have the notes at my house, it was all very fascinating, and when I get the chance can either EDIT this post with my notes to clarify or repost something if the EDIT button is missing.

Lou Ann, I could no longer

Lou Ann, I could no longer EDIT my post and had to start a new reply.  Like you, as aggressive as this cancer is, I do want to know more about it.  So here it goes:

Grade and Stage ae most important as well as the depth of invasion, size of tumor, spread to lymph nodes

There are two broad types of Uterine Cancer:

Type I:  Estrogen dependent, it is more common (85%), younger women, it is well differentiated, favorable prognosis

   Not very aggressive (tend to be Grade 1 or 2)

   Frequently responds to hormonal therapy

   Does not respond well to chemotherapy

   Thought obesity may be part of the cause

   Most patients are cured:  hysterectomy and +/- radiation

   Subtypes of Type I: Villoglandular, Mucinous, Squamous differentiation, Cilliated - all these tend to have excellent prognosis

Type II:  Estrogen independent, less common (15%), Older women, poorly differentiated, less favorable prognosis

   Very aggressive (automatically Grade 3)

   Not very common

   Sometimes has featurs that are called "Glassy Cell" cancer

   Subtypes of Type II:

      Serous - rarely responds to hormone therapy, can respond to chemo, metastasized early even with small volume, usually receives adjuvant therapy chemo/radiation

      Closely resemble ovarian cancer and often found in advanced stages.  Most recur even when confined to the uterus.

      Clear Cell - does not repsonsd to hormone therapy, does not respond as readily to chemotherapy, in general more common in the far east/Asia

      Closely resembles papillary serous, not associated with obesity, present in advanced stages, prognosis is better than papillary serous

Uterine Sarcomas - Cancers that form in the muscle of the uterus rather than the lining

     Malignant Mixed Muellerian tumors (MMMT) - also called carcinosarcomas as they have to malignant components (glandular and stromal)

     Leiomyosarcomas - arise in the muscle of the uterus which does not respond to radiation or chemo

 

Hope you fiind this helpful and please excuse typos.  I typed this in.

Lou Ann M said:

Thanks for the info

Thank you for the information.  I think it is good to know as much as posible about this thing that wants to control my life.  Lou Ann

Yes, thanks

Yes, thank you NoTimeforCancer for your clear differentiation of the various types of uterine cancer. (Even if it does remind me why my oncologist is so careful about regular surveillance of my UPSC, even though I am presently NED!)