METASTATIC BREAST CANCER & CYSPLATIN+GEMCITABINE CHEMOTHERAPY

In Sept - 2011 she has been diagnosed as a case of "Infiltrated Duct Carcinoma ca Left Breast - PT4b N3/10 Mo -Stage 3b & we have admitted her in Lady Hardinge Hospital New Delhi because one of our contacts was Professor of Surgery there. Under the expert supervision of Surgery Head Dr. Manoj Andley & Dr. Ajay Kumar. They have started CAF based Chemotherapy after all the required investigations like : Mamorgaphy, Bone Scan, USG, X Rays, CBC etc. After 3 cycles of CAF based Chemo they done Masectomy & removed the breast after this they have given 3 more cycles of CAF based Chemo. After completion of this they have advised us for Radiotherapy & she has take 25 sittings of Radiotherapy in AIIMS. After this the Doctors of Lady Hardinge Hospital advised us to visit in OPD after every 15 day to keep a vigil eye on patient. We have done exactly same which they advised.

ER- NEG
PR- NEG
HER 2 -  NEG

Now just before 2 months from now like in October 2012 she has seen a little swelling on the Mastectomy site with pus discharged. We visited to or Doctor once again & they have started some antibiotics like Augumentin 625mg & Cefdinir but the problem was still same then they advised FNAC & the report was negative. After some days we have observed a small nodule on left upper arm & we have done a biopsy for that & the result was same that the nodule is infectious with Cance PT4b N3/10 Mor. After that Doctors advised a PET CT SCAN.

The report was:-
Left Breast : Recurrent Disease
Right Breast:
A small Hypermetabolic Nodular Lesion in Right Breast (Inner Upper Quadrant) - Metastic Lesion in Contralateral Breast with Lymph Nodes (Bilateral Internal Mammary Right Axillary Prevascular Right Paratracheal & Left Cerical) Metastases.

No other Hypermatabolic Lesion in rest of the body.

They have started now Dosetoxil based Chemo & now on 12th FEB/13 the 5th cycles is done Chemo done & site of Surgery is very much swelled & the disease is little advance now.

 

After taking 5 cycles of Dosetoxil 160mg there was a little response till 3^rd cycle and when 5^th cycle finished doctor advised for PET CT & report shows MILD PROGRESSION in disease (recent report is attached). Also we have done ER PR & HER2NU 10 days back (report attached), here ER – Positive (0.05) rest are negative.

 

 

Now on 12^th March Doctor started new Chemotherapy with new schedule as below:-

 

Drugs:- Vinorelabin 50mg + Gemcitabin 2gm.

Treatment cycle is:- day1 – then day 8 & then day 15

I need your expert advice on this case & need your appointment as soon as possible.

As of now she has taken 4^th cycles of (Vinorelabin + Gemcitabine) & 22 June start 5^th cycle.

 

 AS ON DATE 17TH AUG/2013-Most latest - Our Oncologist is started CYSPLATIN 80MG + VINORELABIN 50MG. TILL TODAY SHE HAS RECIEVED CYCLE 2 DAY1 TREATMENT.

DOCTOR GIVES HER - DAY1 - CYSPLATIN 80MG + VINORELABIN 50MG AFTER THAT DAY8 ONLY VINORELABIN. BEFORE STARTS CHEMO HE GIVES HER THE INJECTIONS OF NEUPUGEN 1 DAY BEFORE CHEMO & 1 DAY AFTER CHEMO.

 

SOME MAJOR SIDE EFFTECTS ARE OBSERVED BUT AFTER 2/3 DAYS IT DISAPPEAR. 

 

IF ANY BODY COULD ADVISE ME ANY HOME MADE OR ANY OTHER THERAPY WHICH IS FRUITFUL FOR HER, I WILL BE DEEPLY OBLIDGED FOR EVERYBODY.

Looking forward to hear from u soonest.

REGARDS

ABHISHEK