Started CIMETIDIME today. Really happy not following the heard. Naturopathy warning also!

pete43lost_at_sea
pete43lost_at_sea Member Posts: 3,900 Member
edited September 2011 in Colorectal Cancer #1
I want to praise this forum, I get the best life saving information here.
Thanks tanstafl and lisa42 about cimetidime, maybe others have discussed it as well.
Thanks to blake the advice about printing info, or taking reference books and letting doctors decide. It worked well on this occaision.

I visited my local doctor today.
I got referals for surgeon, orders for malaria blood tests, and explained the medical evacuation due to malaria and bowel obstruction.

then I put the life extension foundation "disease prevention and treatment" expnded 4th edition on his desk. opened to page252.

here it explain histamine h2 receptor antagonists . you can read more about this just search for the study Matsumoet al. 2002.

For colorectal duke grade c the 10 year survival is 84.6% versus whatever other odd you get quoted from your bookie. Opps sorry oncologist.

So I just ordered 6 months worth from the Chemist for the grand total of $30 for 6 months.
Yes thats $5 per month, the massive amount of $1.25 week for 10 years. I am committed to this for the decade all being well.

Imagine if it helps, I won't need anymore of those $2000 per week chemo drugs. Well here's hoping.

Just grateful for the all the amazing information we share here. I hope this helps me.

hugs,
Pete

PS My GP is very conservative and worried about my naturopathic tendencies. He refered me to this chilling sad naturopathic story. I wanted to share this link as well, as a warning about dangerous naturopaths.

We have good and bad naturopaths, just like good and bad doctors.
Its up to us to know the difference. Its been called a bullshiiitt detector here before but I thought the warning here is relevant to us.

http://www.abc.net.au/austory/content/2011/s3266961.htm
http://au.news.yahoo.com/thewest/a/-/newshome/9775482/dingle-takes-blame-over-death/

This is a sad story, you can find more info about the specifics if you search.
I still believe in alternatives therapies have helped me with western medicince.
This is just a warning! thats all, but it needs to be shared, at least her passing will not be in vain!

Comments

  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    molecularly targeted naturopathy?
    The Dingles - wow.

    Pete, several caveats. Those odds are for the stage II + III CR cancer mortality only, nothing else. The ultimate determinants of success were perioperative cimetidine with continuous 5FU for a year, and positive CA19-9 and CSLEX biomarkers. Without the biology that produces the biomarkers, there was no advantage, and really, no need for the cimetidine. However, if one is biomarked with both CA19-9 and CSLEX, the nonsignificant 10yr trend was more like 95+% survival if treated with cimetidine+5FU, and relatively fast extinction if not treated with cimetidine - even the biomarked stage II's were all gone in 5-6 years (5Fu only).

    Alone, cimetidine is rarely likely to resolve an established tumor (it has happened, that's how cimetidine's anticancer properties were initially found), usually only reducing the spread. Someday I hope my wife gets to the point she can be even more like the LEF protocol by stopping her continuous UFT-LV chemo (she's stage IV, nodes in the lymph system). We don't do some of the LEF protocol, but we do other less toxic treatments, too, to try to checkerboard the molecular targets. She'll always do lots of natural biochemistries, and cimetidine.
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    tanstaafl said:

    molecularly targeted naturopathy?
    The Dingles - wow.

    Pete, several caveats. Those odds are for the stage II + III CR cancer mortality only, nothing else. The ultimate determinants of success were perioperative cimetidine with continuous 5FU for a year, and positive CA19-9 and CSLEX biomarkers. Without the biology that produces the biomarkers, there was no advantage, and really, no need for the cimetidine. However, if one is biomarked with both CA19-9 and CSLEX, the nonsignificant 10yr trend was more like 95+% survival if treated with cimetidine+5FU, and relatively fast extinction if not treated with cimetidine - even the biomarked stage II's were all gone in 5-6 years (5Fu only).

    Alone, cimetidine is rarely likely to resolve an established tumor (it has happened, that's how cimetidine's anticancer properties were initially found), usually only reducing the spread. Someday I hope my wife gets to the point she can be even more like the LEF protocol by stopping her continuous UFT-LV chemo (she's stage IV, nodes in the lymph system). We don't do some of the LEF protocol, but we do other less toxic treatments, too, to try to checkerboard the molecular targets. She'll always do lots of natural biochemistries, and cimetidine.

    thanks tanstaafl
    the caveats are greatly appreciated, I keep on learning each day.
    so I am curious, I will check for positive ca19-9 and cslex biomarkers with my onc?

    We get on pretty well, I'll email her this thread and see her reaction.

    Given I have had a full 12 rounds of folfox, finished 5 months ago.
    Maybe I have missed the window where cimetidine will help my stage III.

    I would really like to know my biomarker status!

    Given the grim prognosis for those in the study that had positive biomarkers, I guess if I
    had positive biomarkers then some more 5fu and cimetidine may be very benefical?

    hugs,
    pete
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member

    thanks tanstaafl
    the caveats are greatly appreciated, I keep on learning each day.
    so I am curious, I will check for positive ca19-9 and cslex biomarkers with my onc?

    We get on pretty well, I'll email her this thread and see her reaction.

    Given I have had a full 12 rounds of folfox, finished 5 months ago.
    Maybe I have missed the window where cimetidine will help my stage III.

    I would really like to know my biomarker status!

    Given the grim prognosis for those in the study that had positive biomarkers, I guess if I
    had positive biomarkers then some more 5fu and cimetidine may be very benefical?

    hugs,
    pete

    CA19-9, maintenance chemo
    CA19-9 is most informative before surgery, or with active/smoldering disease but still not definitive without the CSLEX, and perhaps some other analyses. A nonzero CA19-9 (result more than 1 or 2), should marginally improve survival benefits by a few percent by removing an extreme non-biomarker subpopulation at surgery, ca 5-10% of stage II-III CRC patients, that simply cannot benefit from cimetidine. CA19-9 should be reasonably priced. On the Asian mainland, one can get a chinese based biomarker battery, called C-12, of 12 biomarkers (no CSLEX) for about $100. I think a CSLEX blood test is almost Japan only, CSLEX tissue staining is mostly rare research groups with the stain.

    Pete, I really can't address your situation or any treatment needs. With my wife, a stage IV patient with a large cluster of para-aortic lymph nodes removed, we've decided to try to stop new cancer cell clusters "from landing" to start new mets with a CIM-UFT-LV-PSK-"2/3 LEF"+++ protocol. We do a lot to minimize the long term impact of even (mild) immunochemotherapy. Last year, her biggest named oncologist projected that this month was the expectable median time to expiry even after both FOLFOX-Avastin and FOLFIRI-Erbitux treatments....

    However she later breezed through that second surgery over the nay sayers, where no new visible mets were found (surprise!), and have had several surprises for the more conventional medicine, less scientifically, minded. We'll soon see what the CT says. CEA seems to be stabilizing around 2, CA19-9 (~20) is still off its low last year even with the lymph nodes, now with some inflammatory contribution. Although these are "normal range" results, I worry about "smoldering" and would like even lower (better) numbers. We are prepared to attrition maturing micromets, nodules or "lunbg thingies" for several years to see if one can resect to a cure while covering common molecular targets for angiogenesis, and maintaining enhanced immune markers.
  • laurettas
    laurettas Member Posts: 372
    Thanks for the links, Pete.
    Thanks for the links, Pete. I have had some experience with this because my parents tend to go to natural doctors at times. One chiropractor/naturopath was "treating" my dad's symptoms a few years after he had colon cancer treatment with a lot of pills and telling him he had a defective ileocecal valve, etc. when what he had was scar tissue closing off his intestines. Then my mom had a spot on her face, found out it was melanoma and the natural doctor told her he could treat it with some lasar procedure that he was just going to class to learn how to use. I was able to talk her out of it and go to the dermatologist to have it removed but it was a fight. This particular doctor told my parents he could cure them of everything they had wrong with them, but he never managed to cure his own diabetes. I always wondered about that.
  • keystone
    keystone Member Posts: 134 Member
    Pete can you share the web
    Pete can you share the web site for the "chemist" I can't find it. Thanks Stephanie
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    keystone said:

    Pete can you share the web
    Pete can you share the web site for the "chemist" I can't find it. Thanks Stephanie

    sorry no link, just real world local drug store
    I got the drugs but am holding off till I get onc ok
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member

    thanks tanstaafl
    the caveats are greatly appreciated, I keep on learning each day.
    so I am curious, I will check for positive ca19-9 and cslex biomarkers with my onc?

    We get on pretty well, I'll email her this thread and see her reaction.

    Given I have had a full 12 rounds of folfox, finished 5 months ago.
    Maybe I have missed the window where cimetidine will help my stage III.

    I would really like to know my biomarker status!

    Given the grim prognosis for those in the study that had positive biomarkers, I guess if I
    had positive biomarkers then some more 5fu and cimetidine may be very benefical?

    hugs,
    pete

    CA19-9 $
    Pete, typically used for the superhigh readings associated with pancreatic cancer, CA19-9 should be generally available and cheap enough for self pay. We've paid $30-50.
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    tanstaafl said:

    CA19-9 $
    Pete, typically used for the superhigh readings associated with pancreatic cancer, CA19-9 should be generally available and cheap enough for self pay. We've paid $30-50.

    thanks tanstaafl
    i will get my head around this stuff and check with onc.
    I think i had 199 done last year, but i gotto go over all the tests.
    its been a busy weekend.

    just thanks as always.

    i hope your wife is going well.

    hugs,
    pete
  • Buckwirth
    Buckwirth Member Posts: 1,258 Member
    Pete,
    I was doing some reading and came across a case that reminded me of the one you posted about the Dingle's.

    This was a Dutch actress, Sylvia Millicam who was dx'd with breast cancer.

    Very tragic tale, made more terrible in that she was taken at a relatively young age.
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    Buckwirth said:

    Pete,
    I was doing some reading and came across a case that reminded me of the one you posted about the Dingle's.

    This was a Dutch actress, Sylvia Millicam who was dx'd with breast cancer.

    Very tragic tale, made more terrible in that she was taken at a relatively young age.

    Thanks Blake,
    Poor girl.

    I have this interesting little piece about cimetidine
    http://www.canceractive.com/cancer-active-page-link.aspx?n=2981

    http://www.lef.org/magazine/mag2002/jul2002_cover_cimetidine_01.htm