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Does anyone have been treated twice with the same chemo and worked?.

pepebcn's picture
pepebcn
Posts: 6352
Joined: Aug 2010

In case you don't have other chemo choice and last time you have used it was two years ago and then worked, is it possible to use it again?.
Just to know about , not needed for the moment.
Thank you all.

johnnybegood's picture
johnnybegood
Posts: 1122
Joined: Oct 2008

dont think i can answer your question but just letting you know my surgen put me back on folfox only because he did not think i could tolerate the diareah from irritatecan.i only had 1 treatment of it and it was decided to go ahead and change to the irritatecan because of the permenant neuropathy the folfox was making it worse and damaging me more.so far so good with my new chemo.as far as your question if you did not have any problems the first time and was able to hanle it well then it should not be a problem.this is only my experience with getting put on the same chemo as i was on in march 2009....Godbless...johnnybegood

pepebcn's picture
pepebcn
Posts: 6352
Joined: Aug 2010

I'm asking just because since you got a reoccurrence they may consider it will not work any more even if had worked very well first time! ,but I don't know if they consider that can be given back after a few years since first treatment!.
Hugs! .
Godbless you as well.

maglets's picture
maglets
Posts: 2596
Joined: Jun 2006

I have been on xeloda twice now....

once for a whole protocol alone and the next next with oxy

seems to be working so far

mags

Erinb
Posts: 295
Joined: Apr 2010

Have you taken the 5-FU?
Erin

Kathryn_in_MN's picture
Kathryn_in_MN
Posts: 1258
Joined: Sep 2009

Unless the chemo didn't work the first time at all, many go back to something they used before. I did FOLFOX, and now FOLFIRI, but my onc says we still have FOLFOX in the bag of tricks to go back to, if FOLFIRI ever quits keeping things under control for me.

He also mentioned that when possible it is good to go off Oxaliplatin or Irinotecan to save it for when you really need it. So it could actually be better if you've been off a certain chemo for a few years before using it again. This is because the cancer won't have mutated to find a way around those drugs like it can if you are on a drug a long time.

pepebcn's picture
pepebcn
Posts: 6352
Joined: Aug 2010

Love to you!

Erinb
Posts: 295
Joined: Apr 2010

My husband's oncologist said NO and I don't know why because FOLFOX worked the first time (not completely but he didn't progress on it). He did say he would recommend Cleveland Clinic if the current chemo stopped working. Maybe they have trials or would recommend folfox again. When we went to Columbus, that oncologist said he would have done the FOLFOX again for as long as my husband could tolerate it up to another 12 treatments. I guess everyone is different.???
Good Question.
Erin

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hi kathryn,

I liked your response and wanted to expand on it, based on reading biology of belief our cancer cells are fighting as hard for survival as we are in a sense. Its not just the mutations that give our particular cancers such tenacity. its the combination of mutation and genetic variation. Some of us have a few tummour cells that are chemo resistant at one point.

for example say 99.99% are wiped out on folfox and you have a break from chemo, you scan all clear, but the tough little basttard cells have survived and are waiting to come back.

Its survival of the fittest at the microscopic cell level. this was all that happened on our lovelly planet for around 3.5 billion years.

I just like the idea of these isolated survivor cells floating our lymphatic system or blood supply and not being able to take root and getting pooed, peed or sweated away.
Not very scientific just huntches.

Why we get liver met, strikes me as the tumour cells floating oround the blood supply they get caught in the blood filtering process. lodge in the liver and then grow. now I wonder if a super healthy liver may be a potential weapon against liver met avoidanc. never read anything on this as a strategy but seems reseonable from what i have learned so far.

Also we have the lung met issue, which seems also like small floating tumours getting caught in the aviloe, the very small lung blood vessels. I wish I had studies biology at uni.

Pete

mukamom's picture
mukamom
Posts: 402
Joined: Oct 2010

folfri with and without avastin, several different times. However this last progression in his liver grew very quickly (three months) and the surgeon is having what they had to resect sent off to New England to test to see what chemo mix will work. So I am assuming that he feels the cancer has mutated. Will be talking to the onc about this next week after Robert is out of the hospital.

Angela

pepebcn's picture
pepebcn
Posts: 6352
Joined: Aug 2010

or was just having nothing during this 3 months!
Hugs!

smokeyjoe
Posts: 1428
Joined: Feb 2011

Are you on chemo. now? If not when was the last time you had to be on any kind of chemo?

mukamom's picture
mukamom
Posts: 402
Joined: Oct 2010

Cyberknife in Nov..after that, he had his bag removed and hernia fixed. Scan in Jan looked good, two "stable spots" we will watch. CEA 1.7 Jan, 1.9 Feb, 4.4 Mar and scan in April showed a 4cm tumor which is now gone after resection and RFA yesterday. Onc waiting now for test results on tumor culture.

Hugs back to ya!

Angela

pepebcn's picture
pepebcn
Posts: 6352
Joined: Aug 2010

Thanks a lot for your comments, I'm happy by seeing Robert is doing well!.
Praying for a fast recovery !
Hugs!

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