Dropping oxi from Folfox4

lexern
lexern Member Posts: 11
edited March 2014 in Colorectal Cancer #1
My doctor is dropping Oxi from my regimen, I have suffered from severe fatigue, mind and body. Will dropping the Oxi help my side effects?

Comments

  • HollyID
    HollyID Member Posts: 946 Member
    #2
    Well, all of that depends on if oxi is causing the side effects.
    While life without oxi is a walk in the park compared to 5-FU and Leucovorin, I still was very tired after infusions when they took oxi off my regimen. I hope you're sleeping well. I usually slept for a couple of days after infusion, even with just the 5-FU and Leucovorin. I was so tired to the point that the room spun and I couldn't walk without holding on to something or else I'd fall into a wall or something. After sleeping, it was over.

    Good luck, Hope you've talked to your onc about this as well.

    Love and Hugs,

    Holly
  • abrub
    abrub Member Posts: 2,174 Member
    #3
    Oxali is notorious for its side effects
    Dropping it will probably make chemo somewhat easier.
  • Unknown
    Unknown
    #4
    HollyID said:

    Well, all of that depends on if oxi is causing the side effects.
    While life without oxi is a walk in the park compared to 5-FU and Leucovorin, I still was very tired after infusions when they took oxi off my regimen. I hope you're sleeping well. I usually slept for a couple of days after infusion, even with just the 5-FU and Leucovorin. I was so tired to the point that the room spun and I couldn't walk without holding on to something or else I'd fall into a wall or something. After sleeping, it was over.

    Good luck, Hope you've talked to your onc about this as well.

    Love and Hugs,

    Holly

    This comment has been removed by the Moderator
  • HollyID
    HollyID Member Posts: 946 Member
    #5
    unknown said:

    This comment has been removed by the Moderator

    Graci, I should have been more clear...
    about what I said. In my mind, I typed it correctly, but I don't think I did.

    When I went off oxi because of an allergic reaction, that left me with the 5-FU and the Leucovorin. To me, it was a walk in the park without the oxi. It did bring on new side effects without the oxi, but to me, they were easy to tolerate. I was never nauseous, or felt bad, no hand or leg cramps, either. I know that people had a hard time with getting neulasta shots because their bones would ache. I never got that either. I was just tired. So fatigued that I could hardly function. Those were the "poop your pants" times because I could barely get off the couch to make it the bathroom because the 5-FU caused diarrhea for me. Everybody's mileage may vary, but that's how it was for me.

    My onc decided I was the poster child of folfox because it really didn't exhibit any side effects for me (Until treatment #7). I wouldn't say that now. I really didn't get neuropathy in my hands & feet until treatment nine and the oxi was pulled on treatment 7. Maybe my body is just SLOW about getting side effects. I don't know. :o) So far, since I've been off chemo for a month, no more side effects have shown up. I still have the neuropathy, but then again, it's better than the alternative. :o)
  • lexern
    lexern Member Posts: 11
    #6
    HollyID said:

    Graci, I should have been more clear...
    about what I said. In my mind, I typed it correctly, but I don't think I did.

    When I went off oxi because of an allergic reaction, that left me with the 5-FU and the Leucovorin. To me, it was a walk in the park without the oxi. It did bring on new side effects without the oxi, but to me, they were easy to tolerate. I was never nauseous, or felt bad, no hand or leg cramps, either. I know that people had a hard time with getting neulasta shots because their bones would ache. I never got that either. I was just tired. So fatigued that I could hardly function. Those were the "poop your pants" times because I could barely get off the couch to make it the bathroom because the 5-FU caused diarrhea for me. Everybody's mileage may vary, but that's how it was for me.

    My onc decided I was the poster child of folfox because it really didn't exhibit any side effects for me (Until treatment #7). I wouldn't say that now. I really didn't get neuropathy in my hands & feet until treatment nine and the oxi was pulled on treatment 7. Maybe my body is just SLOW about getting side effects. I don't know. :o) So far, since I've been off chemo for a month, no more side effects have shown up. I still have the neuropathy, but then again, it's better than the alternative. :o)

    FOLFOX 4
    Holly, were you doing the 3 day infusion like I am with a pump in a fanny pac. Also, were you doing Avastin which is part of Folfox 4, I'm doing the Avastin too.
  • HollyID
    HollyID Member Posts: 946 Member
    #7
    lexern said:

    FOLFOX 4
    Holly, were you doing the 3 day infusion like I am with a pump in a fanny pac. Also, were you doing Avastin which is part of Folfox 4, I'm doing the Avastin too.

    Yes, I did the 3 day infusion.
    I was started on Tuesdays and disconnect day was Thursdays. Thursdays were very happy days for me.

    Avastin, I believe is an added drug to Folfox4. I don't believe it's part of Folfox4 regimen. Someone correct me if I'm wrong. It's my understanding that Folfox4 consists only of Oxaliplatin, 5-FU and Leucovorin.
    http://www.cancercare.on.ca/common/pages/UserFile.aspx?fileId=12846 or http://www.docguide.com/news/content.nsf/news/8525697700573E1885256EAB0061EB14

    I did not have Avastin. We thought about adding Avastin when I became allergic to the oxi, but we both (onc and I) decided to just do the 5-FU and Leucovorin for the rest of the treatments.

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