I am 62 and was diagnosed with stage 4 clear cell in 3/2012, had my kidney removed 4/2012 and 5/2012 lung biopsy with showed lung mets. I have been on Votrient 800mg since June. I was seen at Sloan Kettering and they recommended either that or Sutent...and I am being treated in Binghamton NY. I have had a fair number of side effects, well most I would say.... but my last scan showed excellent improvement with my lung....even being off the med for 2 weeks and them restarting at 1/2 dose then up to 3/4 now full dose again. My liver enzymes were really hign but are now OK. I continue to have a lot of GI stuff...bowel difficulties no matter what I take it seems to sometimes be related to foods but other times not. I was wondering if others are having the same problem and what if anything they have done to help with this....I have Zofran but that is very constitating even at 1/2 dose, and I have miralax and of course the diet stuff prunes etc for the diarrhea I have imodium it is just a constant struggle....I was very depressed at first and am on an antidepressant and my psychiatrist suggested the books forks over knives and The Last heart attack as I have cardiac stents and came off my statin to help the Liver function deal...but those diets are drastic at best.....nothing with a face or mother and father, no oil not even olive oil, no dairy products and no eggs....walnuts very occasionally....anyway if any one has some suggests on what has helped them I would appreciate the input....I too have had the white hair deal...my eye brows are completely white now....it is weird!!!!!