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Has anybody got leg pain from 5-FU?

Fight for my love
Posts: 1530
Joined: Jun 2009

Hi everybody.My hubby is on his first round of chemo and radiation before sugery,the first couple days of this week,he was ok,but since the night before last night,he couldn't sleep well,he got pain in his legs and he feels like he did 20 or 30 miles hiking,but that was more pain than sore, finally he couldn't tolerate anymore,he took Tylenol,then finally he fell asleep.My question is : has anybody ever had the same problem with 5-FU,if you have,how did you solve the problem?and was it ok to take Tylenol?We also called the doctor's office,they didn't give us a clear answer.So we would like to listen to your opinions,lots of thanks to you.

Posts: 125
Joined: Jan 2009

I was on 5-FU no leg problems is your hubby on cholesterol medicines or
other medicines then chemo if so maybe he should call his primary Dr.
Hope he gets better let us know.Oh I know cholesterol meds will cause
leg cramps after taken over a period of time cause I had to change my meds
2 X's

Fight for my love
Posts: 1530
Joined: Jun 2009

qwe,thanks a lot for your reply.My hubby does take cholesterol medicine,but the oncologist said all the oral medications that he is taking now doesn't conflict with the chemo 5-FU.But before the chemo,my hubby never got any pain from the cholesterol medicine.I guess we can't always believe what the doctors tell us,we'd better do more research and pay more attention by ourself.Thank you very much,qwe.

VickiCO's picture
Posts: 934
Joined: Oct 2008

I have severe hip joint pain, and occasional knee pains that my oncologist says is brought on by 5FU. It is always worse the week after chemo (which happens to be this week!) No pain killer touches it...and I am allergic to the Nsaids. Doc says it should gradually get better now that I am finished with chemo.If it doesn't get better, he will test for arthritis.

Many hugs, Vicki

PhillieG's picture
Posts: 4912
Joined: May 2005

It was so long ago that I was on that med I don't remember. I don't think I did. I do know that I can barely get out of bed some mornings because I ache so much. I'm only 51. Once my daily meds kick in it's not so bad.

Fight for my love
Posts: 1530
Joined: Jun 2009

Thank you very much,Vichi and Phil.My hubby's pain only happened in the night,once he gets up in the morning,the pain disappeared.Anyway we will keep an eye on his problem,I am hoping he will get better the next couple of days because the nurse just came to unhook him for the weekend.Thanks a lot,you guys have a good weekend.

daydreamer110761's picture
Posts: 497
Joined: Dec 2008

and nothing touched it. Finally got the doc to give me vicodn, worked and helped me sleep.

Fight for my love
Posts: 1530
Joined: Jun 2009

Thank you daydreamer,thanks a lot for your reply,have a good weekend.

Posts: 881
Joined: Feb 2007

Oh yeah. It started around the 4th round for me and got progressively worse. Along with the neuropathy, it actually worsened for a while after treatment ended, but then gradually abated. It has never gone away entirely--still get days where the long bones hurt (and we won't even get into joint issues...) At first the pain was so bad that they gave me dilaudid, but that is highly addictive. I have since switched to Tramadol and use it as needed. If he can stay away from the narcotics it would be good. A lot of the time narcotics don't actually remove the pain; they just make you not care (LOL!) I'm afraid these strong chemicals that save our lives leave us with potent reminders of their presence. However, I'm just happy to be here, and take each day as it comes. Give your hubby my best and tell him that this, too, is part of the journey.


Fight for my love
Posts: 1530
Joined: Jun 2009

Lots of thanks to you,Kirsten.Yesterday the nurse came to unhook my hubby,so the pain didn't come back until early morning about 4Am,it's strange.The last couple of night the pain happened during the night,now he got unhooked,the pain came in the morning.I guess the pain doesn't care when it wants to come.Anyway my hubby feels a little better to get unhooked and we are glad the first round chemo and radiation are done,my hubby still got another five weeks to go.Thank you very much for your reply,Kirsten.I aprreciate.

Posts: 163
Joined: Apr 2009

Acupuncture took my joint pain totally away in 3 treatments, couldn't even walk before I had the treatments. Awesome.

Fight for my love
Posts: 1530
Joined: Jun 2009

Serrana,thank you very much for the information you provided.I will let my hubby know.Thanks a lot.

lesvanb's picture
Posts: 911
Joined: May 2008

Acupuncture also has worked in keeping me relatively pain free during treatments, especially effective before and after surgery. My joint/leg pain/ache increased after ending my last chemo treatment. I take ibuprofen (had liver surgery so stay away from tylenol) before I go to bed which helps me get to and stay asleep. The pain in the back of my calves has woken me up on occasion.


Fight for my love
Posts: 1530
Joined: Jun 2009

Thank you very much,Leslie.I will let my hubby know Acupuncture is an option too.I appreciate your answer.Thank you.

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