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Luteolin

SandiaBuddy's picture
SandiaBuddy
Posts: 897
Joined: Apr 2017

Luteolin (not to be confused with Lutein) seems to me to be one of the lesser known flavonoids and dietary supplements (available from Swansons).  I have been taking it for a couple of months.  The results summarized in this study are preliminary but intruiging.

link (then click download PDF)

Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal herbs, and fruits. It acts as an anticancer agent against various types of human malignancies such as lung, breast, glioblastoma, prostate, colon, and pancreatic cancers. It also blocks cancer development in vitro and in vivo by inhibition of proliferation of tumor cells, protection from carcinogenic stimuli, and activation of cell cycle arrest, and by inducing apoptosis through different signaling pathways. Luteolin can additionally reverse epithelial-mesenchymal transition (EMT) through a mechanism that involves cytoskeleton shrinkage, induction of the epithelial biomarker E-cadherin expression, and by down-regulation of the mesenchymal biomarkers N-cadherin, snail, and vimentin. Furthermore, luteolin increases levels of intracellular reactive oxygen species (ROS) by activation of lethal endoplasmic reticulum stress response and mitochondrial dysfunction in glioblastoma cells, and by activation of ER stress-associated proteins expressions, including phosphorylation of eIF2α, PERK, CHOP, ATF4, and cleaved-caspase 12. Accordingly, the present review article summarizes the progress of recent research on luteolin against several human cancers.

beaumontdave's picture
beaumontdave
Posts: 997
Joined: Aug 2013

First suppliment I've read that pertains to gliomas, wish we had things to try back when it might have helped....................................Dave

JanJan63's picture
JanJan63
Posts: 2482
Joined: Sep 2014

Interesting. Thanks for sharing!

Jan

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