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Is the night time the right time for 5-FU?

coloCan
Posts: 1956
Joined: Oct 2009

Is 5-Fu given via a pump to take home for 46 hours done so because during the night time liver enzymes that detoxify the liver are more abundant than during the day thus making the 5-Fu less toxic?-

 

never thought about this......

abrub's picture
abrub
Posts: 2131
Joined: Mar 2010

I was told that 5FU has a very short half-life (something like 10 minutes), so that to ensure that there is some active in your system, it is given in a 46 hours drip.

Alice

coloCan
Posts: 1956
Joined: Oct 2009

from last sentence of second paragraph

http://medicalxpress.com/print284730928.html

 

and given the idea that supposedly  2/3s of the efficacy of FOLFOX is derived from the 5-FU it must be pretty potent yet i always thought it was the oxi that was the stronger

tachilders's picture
tachilders
Posts: 313
Joined: Jun 2012

Might also be to minimize side effects. I always get a bolus of about 950mg and then like 5000mg for the 46 hours. 

danker
Posts: 1253
Joined: Apr 2012

When I was getting 5-fu,it was with a chemo pump delivering 1 1/4 cc Hr 24/7. That lasted all 5 weeks I was getting radiation. 2010 was quite a year, but the resection,ileostomy,and reversal worked! My colonoscopy in 2011 showed NED.  Been NED ever since living a normal(?) life.

coloCan
Posts: 1956
Joined: Oct 2009

 i wonder what the astronauts have to say about this "risk"

www.myhealthnewsdaily.com/3711-space-travel-colon-cancer-risk.html

manwithnoname
Posts: 404
Joined: Jun 2012

post on circardian rythym and Chemo (here somewhere) ,  the right time makes a huge difference on effiacy and side effects

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