IL-2 + vitamin A

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manwithnoname
manwithnoname Member Posts: 402
edited November 2014 in Colorectal Cancer #1

" a significant improvement, with respect to NCI SEER data (*), could be observed in the 5-year OS rate for the most common treated metastatic cancers: Breast cancer 42.7% vs. 23.3% *, lung cancer 26.4% vs. 3.6% *, colorectal cancer 43.6% vs. 11.7%*, renal cancer 23% vs. 11% *. No WHO grade 3 or 4 toxicity was observed, while grade 2 cutaneous toxicity and fever occurred in 20% and 13% of patients, respectively. Mild hypothyroidism and grade 2 triglyceride elevation was observed in 5% and 15% of patients, respectively. 1 patient had to stop treatment for grade 2 urticaria. Conclusions: These data show that the administration of IL-2/RA, determines, with a modest toxicity profile, a sustained improvement of NK cells, a decrease of VEGF, and unexpected 5-year survival rates"

 

http://clincancerres.aacrjournals.org/content/7/5/1251.full.pdf

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  • janderson1964
    janderson1964 Member Posts: 2,215 Member
    #2
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    Thanks for posting Tony. Very

    Thanks for posting Tony. Very interesting.

    How is your son doing.

  • manwithnoname
    manwithnoname Member Posts: 402
    #3
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    janderson1964 said:

    Thanks for posting Tony. Very

    Thanks for posting Tony. Very interesting.

    How is your son doing.

    Hi Jeff

    we think he is doing ok, scan is over due. considering ^ this immunotherapy if news is bad.

     

    If scan is good i will post pics. no matter what he has inspired a clinical trial for HBOT and brain tumours.

  • janderson1964
    janderson1964 Member Posts: 2,215 Member
    #4
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    manwithnoname said:

    Hi Jeff

    we think he is doing ok, scan is over due. considering ^ this immunotherapy if news is bad.

     

    If scan is good i will post pics. no matter what he has inspired a clinical trial for HBOT and brain tumours.

    I look forward to the pics.

    I look forward to the pics.

  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #5
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    Interesting

    Interesting paper Tony.  Not sure how to address the vitamin A and D3 interaction competing for the receptors.

    And what is the cheapest we can get more IL-2?     Cimetidine increases  IL-2 production.  Using the "Walmart discount std" (some places try to be a dollar cheaper on 90 days), 800 mg ca $3.50,  1600 mg per day under $7 per month.   

  • manwithnoname
    manwithnoname Member Posts: 402
    #6
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    tanstaafl said:

    Interesting

    Interesting paper Tony.  Not sure how to address the vitamin A and D3 interaction competing for the receptors.

    And what is the cheapest we can get more IL-2?     Cimetidine increases  IL-2 production.  Using the "Walmart discount std" (some places try to be a dollar cheaper on 90 days), 800 mg ca $3.50,  1600 mg per day under $7 per month.   

    Hi Tans

    I will look at ways to raise IL-2 , I know here injections are available( at a cost ) but Kai is still banned from treatment.

    JFYI another kid followed Kai into HBOT, results yesterday SHRINKING after 2 months treatment. Shrank more than 13 months of high dose chemo.

  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #7
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    manwithnoname said:

    Hi Tans

    I will look at ways to raise IL-2 , I know here injections are available( at a cost ) but Kai is still banned from treatment.

    JFYI another kid followed Kai into HBOT, results yesterday SHRINKING after 2 months treatment. Shrank more than 13 months of high dose chemo.

    thnx

    Yes, thanks, keep it coming on the HBOT results Tony.  We need more real life HBOT examples, eventually on the mCRC side.     

    I ran getting a personal chamber past my wife, and she balked on the cost and/or features.    Basically, it's tough sell short of cancer's gunpoint situation, "do it or die" - she would want HBO first class commercial grade, not some coffin model.  Normal office prices seem unaffordable.  She's partially complacent since she's medically stable (I think there is a suppressed macro met, >4mm, not yet visually identified, but still low load "NED if you squint") and  some of the HBO features come with the IV vitamin C (like inhibition/destruction of HIF-1a).

    Treatment involvment, learning curve and affordability are always issues. We typically commit on a sustained, (long) life cycle basis.  e.g. IV vitamin C was a big commitment because toe-in-the-water or half measures won't do much for very long and there was a learning curve, too. 

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