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The latest from the AACR

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

Hi All..!  I had not posted much here, and it is time..  I just got back from the annual AACR conference in San Diego.  American Association for Cancer Research.  No, I won't be typing that out again here..   I attended this conference as a Survivor / Advocate, which got me there for FREE..!

There were in the range of 25,000 people.. not sure of the final number yet... but it was a lot..!  And there were a bunch of different types of presentations.  There were hour plus long seminars, there were 30 minute presentations, there was a large Vendor area, and my favorite the poster areas.  There were 3 sections of the large ballroom with poster areas.  Each poster area had like 30 poster boards times 30 rows, both sides.. a LOT of posters.  The posters were up for half a day, then another group put up their posters.  I doubt any of you would be surprized to hear my poster had motorcycles on them..! Cool

OK, you name the topic and there was something there... every kind of Cancer, and hundreds of researchers with their own ideas.  But this year there was a huge focus on Immunology..  Some / many.?  think Immunology could end up being the.....  CURE..!   Now do not get over excited, Immunology has been around for about 100 years.  And little to show for it in the past...  It kind of went out of favor.. but it has been revived..!  Keep in mind that it is hard to accept change..  we all know how hard it was when we heard those three words.. "You have Cancer.."  The science world is not different.. a new idea often gets shunned..  And it gets worse.... you have people with many different back grounds and training.. Chemists, Biologists, Physicists, etc.. and they do not usually play well together... rarely do they collaberate.  But there is a push for such collaborations to happen..!  I won't even try to list all of the areas I looked at in just 3 days..

OK, so here is a link to some, only some of the presentations... not everything is on line yet.. and a lot will never be on line, as many were not recorded.

http://webcast.aacr.org/m/2014annual/d/7?link=nav&linkc=date

Now in case you have not been paying attention, my hot button surrounds CD47 and the possible upcoming Anti CD47 treatments.  Here is a link to Dr Weissmann's 30 minutes session... much of which is not understandable by everyday people.. but if you sit through it you will hear tidbits of what you will understand.. and feel Dr W's enthusiasm for his work.  He is not afraid to put himself out there and comment on others.. I like him..!  And when you hear his opening about prior research getting shut down, then later you hear that he is working independent of outside influence, I think you will see he is trying to be as pure as an old guy can be... heh..  Here is a direct link to his talk...

http://webcast.aacr.org/console/player/23028?mediaType=podiumVideo&

Ron

 

sblairc's picture
sblairc
Posts: 131
Joined: Feb 2014

I've been following the online articles as they trickle in about some of the stuff presented on at this conference. So far I hadn't seen anything specific to RCC. Did you happen to learn anything related to non-clear cell RCC? My husband had chromophobe and I keep hoping for new developments!! Hope you enjoyed San Diego. 

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

Yes, B.C, is the most common type of Cancer.  One of my mentors stated that noone dies (directly) from B.C. any more.. from Mets, yes but not the main tumor.  OK, if you look at the rare type Cancers you may find something on Chromophobe..  I know I saw it mentioned somewhere..  I will look for it as well...

Ron

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

I will also add, and sorry if this upsets some folks.. is that a few of the new thinkers are going a different direction with B.C.  I was amazed that some doctors do not do surgery for B.C.  Their new thinking is keeping that main tumor and treating with Chemo.  This totally shocked me as I know a few women that had to mentally go through that anguish.  But, the thinking is that with this type of Cancer all the tumor effort will go towards that main tumor and there is a less chance of Mets.  This is a novel approach.. and is much different than in the past for sure.  That said, with Cancer in general, some treatments today differ than they did just a few years ago.  With the new treatments coming to trials,  we may see another shift in treatment strategy.

And with the "promise" of the new research on Immunology, surgery for many types of Cancer could no longer be routine.  Surgery could be only in rare cases... this is huge for all of us, well huge for the next generation of Cancer patients as most of us already had at least one surgery.  The whole new idea is that the Immunologic treatment will cause our own body to "eat" the tumor and in some cases repair the damage.  One speaker used the term.. Star Trek medicine..  This is exciting.. hope we are all around to benefit from it...

Ron

sblairc's picture
sblairc
Posts: 131
Joined: Feb 2014

Since my husband's diagnosis, I like to think about what the future will bring for research and treatment. Kidney cancer treatment has come a relatively long way in a short amount of time. This helps me stay positive. Thanks for sharing.

MMondi1
Posts: 11
Joined: Jun 2013

Great stuff Ron.   Any idea why Kidney cancer and a few other cancers are in black vs red on the CD 47 list of cancer slide?

 

Only thing I could guess from the slide is it has something to do with progenitor cells.

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

I and others have noticed that. I am now at Stanford and will try to find out. But kidney cancer was mentioned as a success in the mice test.

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

Well no chat yesterday.. but next week I will review this with my Onc.. see if she can find out the answers for us..  Hope.. this is what we have.. and there should be plenty of hope to go around..!  There are more Cancer conferences coming up, and I see Immunology is a hot topic.  The term "breakthrough" is being used a lot..  Hang on everyone.. we may be able to live until something else gets us.. and hopefully that is a very long time indeed..!   I did hear comparisons to HDIL-2 but without the super harsh side effects and a much higher response rate.  I want to go to this dance..!!  Smile

Ron

foxhd's picture
foxhd
Posts: 1935
Joined: Oct 2011

Something tells me that these immunotherapy treatments might work. Is there anyone who wouldn't want to give them a shot? Sometimes I get baffled when I realize just how fortunate I am to have recieved both of them. I can't wait for everyone to get a chance.

sblairc's picture
sblairc
Posts: 131
Joined: Feb 2014

"Genetic analysis revealed the patient carried a mutation in the TSC2 gene that helped make her tumor susceptible to Novartis AG (NOVN)’s Afinitor, used for kidney and breast cancer. The treatment works on a biological pathway called mTor that’s linked to the mutation.Now, researchers plan to screen other patients for mutations to the mTor pathway and enroll them in clinical trials using the drug. These patients wouldn’t be selected based on the type or placement of their tumors, but rather based on molecular profiling, Wagle said."

 

 

http://www.bloomberg.com/news/2014-04-11/cancer-miracle-patients-studied-anew-for-disease-clues.html?cmpid=yhoo

NanoSecond's picture
NanoSecond
Posts: 532
Joined: Oct 2012

Yes indeed.  This is why a few mRCC patients respond extraordinarily well to mTOR inhibitors whereas many others do not.

sblairc's picture
sblairc
Posts: 131
Joined: Feb 2014

With my husband having chromophobe, I was happy to see this aspect of things. I hope this becomes a way of the future for acceptance into clinical trials.

 

I recall reading an article that oncologists really want to have cancers thought of more about how they behave rather than where they are located and that this paradigm shift is an important one for the future of treatment. It was a while ago when I read this article, wish I had bookmarked it. 

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

OK, so I am not sure where the best place to post this is... but here ya go...!  Speaking on Immunology... this is a great video.. and most of it is easy to understand...  All good news..!

Be Well All..!!

Ron

http://www.scientificamerican.com/article/wolchok-video-who-knew-cancer-has-an-off-switch-video/?WT.mc_id=SA_SA_20140415=

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

OK, this is not from AACR, but from the KCA... a long video with lots of great info about Dx and treatments and clinical trials, etc...  The first 45 minutes or so could be skipped, but from then on, there is some good stufff....

Ron

https://www.youtube.com/watch?v=kAXTIyYQvqY

 

GSRon's picture
GSRon
Posts: 1272
Joined: Jan 2013

Hi All..!  Yes me going on about CD47 again.  Still no Clinical Trial listed.. still the latest info from 3-14 says this summer.. But I did find this link interesting.. http://www.ncbi.nlm.nih.gov/gene/961

I almost forgot.. the latest CD47 info stated that Clinical Trials may also happen in the U.K... so all you folks from over the pond.. stay tuned as well.. I ca NOT forget my pals over there..!! Cool

Hang in there....

Ron

Djinnie's picture
Djinnie
Posts: 787
Joined: Apr 2013

Thanks for the update Ronnie, it will be fantastic if this could lead to vaccinations for future generations. 

 

Djinnie x

 

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