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molecular tumor profiling

vinaykumar
Posts: 66
Joined: Dec 2012

found out that there is molecular tumor profiling avalible in india and at the hospital my dad is being treated at. however i am not sure how useful  genomic testing is. Are there folks here who have been able to action on the findings of genomic testing? finding out abt the wrong genes are right chemo is one thing but having your onc action on it is another...

saussureainvolucrata
Posts: 52
Joined: May 2013

i have the same question. i know scubadan had a genomic (genetic? not sure what the right word is) profiling test done recently, which i remember from his earlier post is supposed to be a relatively new type of test. i've been wanting to ask him about the exact name of this test. there are others indeed who have done similar profiling tests. but my question has always been: from what i understand, these tests help determine the efficacy of certain chemo medications. but aren't there only about 5 or so types of chemo medications out there? if the number of options is limited, i am puzzled about how useful detailed genetic/genomic profiling can be? 

lp1964's picture
lp1964
Posts: 912
Joined: Jun 2013

As I understand it there is three types of testing.

1. Genetic test to determine whether you have certain genes that increase the possibility of cancer in you or your relatives.

2. Genomic testing is performed when you already have cancer and they look into your cancer's DNA to see if the cancer is a certain type. This is important because certain type of colon cancers will not react to certain chemo drugs.

3. Chemo sensitivity test is done after a small piece of the cancer is removed. The want a small piece of the living cancer within 24 hours. They will keep these cells alive and test different chemo dugs or combination of different drugs and see how the cancer cells react. 

I'm having the last one done or go to the Rational Therapeutics website.

 

 

saussureainvolucrata
Posts: 52
Joined: May 2013

O'k, Laz, this is a good starting point for orientation. I will sit down and do some research now. Please keep us posted about the results of your chemo sensitivity test. 

lavleen
Posts: 1
Joined: Nov 2013

Does anyone know where Chemosensitivity test with patient samples are done in India?

Lavleen

lp1964's picture
lp1964
Posts: 912
Joined: Jun 2013

I know a place here in California, but they need to get the sample in 24 hours after removal. The test is $4000. 

Do an Internet search, maybe there are options in India as well. 

Good luck, 

Laz

DD3's picture
DD3
Posts: 44
Joined: May 2013

We had some genetic testing done on my wife's tumor.  More concern about the possibility of "passing" something on to our kids. Which was of huge concern to her.  After seeing a geneticist and going through biology 101 again.  We were re-assured.  Nothing in he initial testing showed that she if fact passed "bad" genes onto our kids. 

Some research folks can do on our own.  Google Lynch syndrome.  Pretty informative.

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