Oct 11, 2013 - 9:45 pm
Im new to the board. I found the CSN by searching about Arimidex side effects and indolent Breast Cancer. Ironically, in doing so I read some posts by Cindy and Doris that sounded like my mom. Hearing what they wrote has given me some hope.
My mom was diagnosed in 1988. She had a large tumor and 7/17 nodes were positive. She got CMF at that time. Her 2 neu wasnt around then. Was not given Tamoxifen as she was premenopausal state and her onco was ardent about not using it. Did well and cancer free until three weeks ago.
Now, just three weeks ago diagnosed with what is thought to be recurrence. Spine, ribs, one spot on skull and two nodules small side in liver. We were told this most likely is "indolent" as prelim biopsy showed very high Estrogen receptors ( final path 99%). However this tumor is her 2 neu positive but the PR is negative. Obviously different from her previous tumor. Onco thinks still a recurrence where the tumor cells have started expressing her 2 neu and hes confident given a 25 year disease free time frame that her original tumor was her 2 negative.
I read that Strong ER positive when PR is negative is really reallya bad sign since it means she will not respond to Tamoxifen or Arimidex. The ER is 99 % , i was shocked at how high it was thinking what a good response she would have only to just today be told the final path is PR negative and her 2 positive.
I read one of Doris's post and saw she said she was ER positive and PR negative back in the 90s and shes having and had good responses to hormonal therapy. That gave me some hope. Also reading Cindys posts about her recurrence 20 plus years later and her positive responses gave me even more hope.
Im so scared for her now. She completes two week radiation and is on Faslodex and Arimidex. Now onco wants to start Herceptin.
For the record my mom was 46 at diagnosis.