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Irrinotecan and 5fu pump

Hooley's picture
Hooley
Posts: 149
Joined: Aug 2012

Is there anyone who like me has had both these treatments.   Eg hour and half infusion at clinic at then a take home cad for 48 hours. What I am wondering has anyone stopped taking home the 5fu pump and if so any adverse effects ?

Roddy2
Posts: 21
Joined: Dec 2012

Hi Hooley,

Mate of mine has been on the Irinotecan, Avastin and 5fu pump for some time now and not likely to change in the near future. Has had 30 plus doses. He gets hit pretty hard by the Irinotecan and feels crook right from when they start to infuse till 4or5days later. Worst thing is that he has to travel for  a couple of hours by plane to get to the centre each fortnite. But to see the best Oncologists, you have make this effort. They are the ones  helping us get to see another day.

cheers

Roddy

johnnybegood's picture
johnnybegood
Posts: 1122
Joined: Oct 2008

in 2011 i had irrinotecan+avastin before and after my liver resection.my onc decided to not give the 5fu because irrinotecan is known for the diareah side effect and he thought the xtra 5fu combined would cause even a worse effect of diareah.i did well on that ,it shrunk my tumors for the liver resection and after it held my lung tumors back.i may be looking at going back on that cocktail in the near future dont know the plan yet.good luck and i would definately talk to your onc about it...Godbless...johnnybegood

smokeyjoe
Posts: 1428
Joined: Feb 2011

Are the xeloda pills available for you??    Some people have the option of taking the pills instead of the pump.  

Hooley's picture
Hooley
Posts: 149
Joined: Aug 2012

Had xeloda during my second year. Kept things stable for while then started to grumble. Bugger 

Hooley's picture
Hooley
Posts: 149
Joined: Aug 2012

Hi johnnybegood

am interested in your lung tumors.  How many? Size? Location? Surgery?    What shrunk the lung ones and over what period of time?

gods richest blessings 

Hooley's picture
Hooley
Posts: 149
Joined: Aug 2012

Tks roddy.  Yeh they say irrinotecan is the tuff stuff. But as u say keeps us going

danker
Posts: 736
Joined: Apr 2012

I had fu5 pump giving me 1&1/4 Ml per hour 24/7 for 5 weeks.  Was also getting radiation those 5 weeks m-f.  Then 6 week rest before resection. It worke!! I have been NED nearly 3 years.  Hope you waill too. Good luck!!

Hooley's picture
Hooley
Posts: 149
Joined: Aug 2012

So excited for u.  Think I've got to decide if i try lung surgery or not.  im bit tired of 3 yrs chemo.  But am grateful to still be here!

Scubadan (not verified)

For about 3 & half yrs I was on the Folfiri regimin every  two weeks. Infusion started with the ususal dexamethasone and granistron (antiemetic), then an hour + infusion of leukovorin. Then the Irinotecan.  Then the avastin. The loading dose of fluororacil (FU) should take about 8-10 minutes, very slow push to bring the blood levels up tp theraputic value. The key is to start the 5FU pump quickly after the loading dose because the 5FU only has a halflife of 15 to 20 minutes. If the theraputic blood level drops after 30 or more minutes of the loading dose, the slow infusion on the pump won't be as effective.  Also if the loading dose is pushed too fast it made me nauseated and feel bad. I don't get nauseated easily. I always let the nurse know that I was timing her push so she wouldn't hurry. Like I said the 5FU has a very short half life so by a few hours after D/C the pump it will be gone, the Irinotecan and  Avastin last longer, but you'll feel prettry good after a couple of days. I have never had any trouble with the pump removal or soreness at  the skin insertion site. They will always load the catheter with 100 units per ml of heparin to keep the catheter from clotting when the pump is removed.  Going into chemo with an attitude of being sick all the time will probably make it so. Go in with the attitude of the tough guy that you will be not let this ruin your week. Be strong and live long.

Dan

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