Sep 05, 2013 - 12:54 pm
First time posting but everything is getting overwhelming.
My husband was diagnosed 30 months ago with Stage IV Colon Cancer with mets to the lymph nodes, liver and bone. After seeking several second opinions all come back the same - He was not a candidate for surgery. He underwent 14 months of folfox treatment. He had to stop due to allergic reaction. At that point the canncer was no longer detected in the bone and lymphnodes, The primary tumor site although still present did not "glow on the PET scan and the liver was down to two active sections. Explored the surgery option again, but due to the location of the lesions, it was not possible. It was decided to have some quality of life and he just took 5-FU for approximately six months. On the repeat CT Scan there was some enlargement of lymph nodes and the primary tumor site. It was decided to do a PET Scan and the primary tumor was active again along with lymph nodes and and enlargement of activity in the liver. He did four cycles of folfiri. The side effects were awful. The CT scan was repeated. There was continued growth in the primary tumor as well as enlargement in the liver. Folfiri was not working. Sought out additional opinions and decide to go to a special clinic for desentization of oxalyplatin. This worked for 6 cycles, improvement was noted on the CT scan. Primary tumor reduced, reduction in liver leasions and the lymph nodes were not remarkable. Then on the 7th, 8th and finally 9th rounds he suffered a series of setbacks. Rigors and fever. His last cycle his heart went haywire and his platelets plummeted. He had an hemolytic reaction to the oxalyplatin. Thus he can never receive the oxalyplatin again. Meanwhile since his last treatment he had three weeks of fever of unknown origin rises to in excess of 102 F every night. He has had repeated tests and blood work ups. Nothing can be found so now they are saying it is "Tumor Fever"
So we are left with very few options. He could go to a medication that was approved last fall. But the oncologist was open and honest in saying the side effects he is seeing are considerable and the success rate was small. We could try for clinical trials. A phose 1 and and phase 2 are open and he would qualify. So now we need to make the decision of which direction to go. The approved treatment that the experience of the oncologist says it is not a beneficial as they had first hoped. A phade one clinical trial, a phase 2 clinical trial or just opt for no more treatment. We go tomorrow to learn more about hte clinical trials.
Everything is just getting overwhelming. Any advice would be greatly appreciated.