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Very encouraging!

sunflash's picture
sunflash
Posts: 154
Joined: Aug 2011

Very encouraging! Keep your fingers crossed ladies! This could very well be a breakthrough

 

http://www.nypost.com/p/news/national/testing_starts_creates_homegrown_4jSHWpWFBEkczPTFque7VM

 

Stanford researchers are on track to begin human trials of a potentially potent new weapon against cancer, and would-be participants are flooding in following the Post’s initial report on the discovery.

The progress comes just two months after the groundbreaking study by Dr Irv Weissman, who developed an antibody that breaks down a cancer's defense mechanisms in the body.

A protein called CD47 tells the body not to "eat" the cancer, but the antibody developed by Dr Weissman blocks CD47 and frees up immune cells called macrophages — which can then engulf the deadly cells.

 

The new research shows the miraculous macrophages effectively act as intelligence gatherers for the body, pointing out cancerous cells to cancer-fighting "killer T" cells.

 

The T cells then "learn" to hunt down and attack the cancer, the researchers claim.

“It was completely unexpected that CD8+ T (killer T) cells would be mobilized when macrophages engulfed the cancer cells in the presence of CD47-blocking antibodies,” said MD/PhD student Diane Tseng, who works with Dr. Weissman.

The clinical implications of the process could be profound in the war on cancer.

When macrophages present "killer T" cells with a patient's cancer, the T cells become attuned to the unique molecular markers on the cancer.

This turns them into a personalized cancer vaccine.

“Because T cells are sensitized to attack a patient’s particular cancer, the administration of CD47-blocking antibodies in a sense could act as a personalized vaccination against that cancer,” Tseng said.

The team of researchers at Stanford plan on starting a small 10-100 person phase I clinical human trial of the cancer therapy in 2014.

 

jazzy1's picture
jazzy1
Posts: 1387
Joined: Mar 2010

oopsie duplicate

jazzy1's picture
jazzy1
Posts: 1387
Joined: Mar 2010

This is so encouraging and nice to read about  clinical trials  on humans next year,,,,,WAHOO!!!  Hoping all this hits in our life time as I never want anyone else to go thru what many of us have have endured.

My college-aged daughter mentioned one of her friends in med school, was part of this research team......

Appreciate the post,

Jan

jazzy1's picture
jazzy1
Posts: 1387
Joined: Mar 2010

Darn it again...

Fayard's picture
Fayard
Posts: 343
Joined: May 2011

Excellent news!

sunflash's picture
sunflash
Posts: 154
Joined: Aug 2011

I agree that it's very exciting to see that new inroads are being made to target ALL cancers........not just the common ones. This gives me a lot of hope that we'll see some amazing things in future treatments. It seems like very major treatments are found "by accident". Penicillin for one. God bless the dedicated researchers! 

Jan...very interesting that your daughter knows one of these researchers! My son does medical research also. He's in grad school researching blood clotting disorders. I can't even begin to understand what he tells me.......how'd these kids get to be so smart? LOL!

 

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