Mar 26, 2013 - 7:23 pm
Hello my dear Pinks
I have not been posted lately, however you are always in my thoughts. In the end of February I have completed a full 8 months (16 cycles) of Chemotherapy - Xeloda. My body could not take it anymore, however I am very thankful to this drug and the help I did get from it. What is my next treatment now?
I have been involved with screening, qualification, and enrollment in clinical trials of Faslodex +BKM120 (PI3K inhibitor) for metastatic BC. In order to be qualified for the the study I had to go through series of tests, had enough tumor tissue for characterization and genetic testing, be positive, and optimistic, and healthy taking long and short walks, yet having stage IV, which stopped responding to previous therapy. What I learn through this process that I am still sick enough to be qualified for the study, having several lytic lesions, and healing sclerotic lesions and fractured rib. Just going through this process and every little test and scan has made me feel much worse than before. No wonder when I have been constantly remainder that in fact I am stage IV. Initial research has shown that this drug, BKM 120 is crossing brain barrier, which could cause depression therefore the Sponsor, a pharmaceutical company, wants candidates to be happy with ongoing life, optimistic, having overall a pretty good health, yet have mBC (LOL).
Unfortunately it is a double blind study, therefore we do not know that it even worth to try, however per my doctor suggestion I am doing it. Almost 3 weeks has passed before I was enrolled and today I have had my first treatment - Faslodex 2x250 mg shots. Any helpful tips for mitigating its side effects will be highly appreciated. In addition, 10 tubes of blood were collected. Two weeks from today I will be given BMK120 or placebo. My chances are 50/50%. Since the cancer is aggressive and does not respond to anti-estrogen medications, my doctor thinks Faslodex and X-geva will be not enough to keep cancer under control. Let's hope I will be given a chance. if not… at least I will help development and approval of this new drug to reach market and becomes BC treatment.
Yesterday I got a very positive news from Claudia:
"And the good news is I have gained 8 pounds , better news is my tumor markers are down 48 points and the best news is my liver enzymes are normal. Yes I still have cancer but I'm getting well"
Thank you everyone, who is help me throughout this journey. I am too tired and going to rest today
I wish everybody to be healthy surrounded by love and hope for the best to come.
Happy Spring, Passover & Easter - the holiday of your choice.