Jan 21, 2013 - 9:07 pm
During my warrior intel outings I dug hard into the whole induction chemo regime some are offered these days. What I found interesting was all the studies dried up around 2010-2011. I did wonder but had no idea at the time. The one key study I was looking for was the one that evaulated TPF sequential CRT vs CRT only. I did find one study that was phase III but never fully vetted or published in peer journals such as the New England Journal of Medicine.
Last week my MO told me I would not find much any more due to patent on Taxotere expiring in 2011. Both Cisplatin and 5-FU are also generically available so there is no monetary incentive for drug companies to invest or support drug trails that will not yield any return on investment. It also explains why there were several studies comparing TPF vs PF vs either against standard CRT.
On the soapbox for a second. I am a capitalist and small govt. guy to the core yet when I heard this it really made me think that at least in some areas more government support is needed. I have heard other diseases with low financial reward are left to the wayside while other clearly others that have no life saving value (I'm sure you can think of a few) yet are deluged with $$ for research, FDA approval and hard marketing to maximuxe $$. OK, off box.
Hopefully, for those who go down this reasarch path will at least understand why things dried up for this course of treatment.