Jan 18, 2013 - 2:18 pm
I am KRAS wold type and am currently on erbitux maintenance chemo.
My doctor has also recently started me on low dose aspirin (75 mg) daily after my resection of colon and liver. He advised that I should get the pik3ca test done.
The test is done on the tumour sample and the test has me identified as pik3ca mutation in exon 9.
The prognosis of persons who are KRAS wild type and having pik3ca mutations not very good for overall survival , it seems. However, use of aspirin for mutated pik3ca indicates better survival statistics. This is what I read when I do a search. Also, there are some papers indicating that only if exon 9 and exon 20 are both mutated in the pik3ca test then the prognosis is not good. If someone has one mutation then there is no such bad prognosis. Also for pik3ca mutation in exon 20 it seems that biologics like erbitux ( EGFR affecting drugs) don't seem to work for reduction of tumour etc.
Has anyone got this test done and can advise me or throw some more light on this matter?