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Eligard vs Lupron?

ralph.townsend1's picture
ralph.townsend1
Posts: 359
Joined: Feb 2012

What is the difference between the two?

VascodaGama's picture
VascodaGama
Posts: 1734
Joined: Nov 2010

Many guys have asked your question but not many had a chance of experiencing both drugs and report about difference in symptoms. I believe that both act equally and produce the same side effects.

In fact, both drugs use the same active ingredient, leuprolide acetate, and both are used for the same purposes in PCa, to cause castration, and both are given in injection form, but they belong to different manufacturers, and that may be the difference.

The manufacturer of Eligard sells subcutaneous injections in four different doses to be taken every one, three, four, or six months. And the Lupron is available in two forms; subcutaneous injections for daily use or Lupron Depot as a long-acting intramuscular injection for one, three and four months use.

Some guys do better with subcutaneous and some with intramuscular.

 

The main ingredient in both drugs is leuprolide which is a synthetic form of the Gonadotropin-releasing hormone (GnRH a hormone found naturally in the body), produced by the hypothalamus.

The GnRH controls the release of two other hormones from the pituitary gland, specifically the luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These two hormones are sent down to stimulate production of testosterone in the testicles. They act like “orders” from the brain.

 

Normally, when GnRH is released by the body, LH and FSH levels increase and more testosterone is produced, however, once the body becomes “satisfied” the pituitary stops sending the “orders”.

The intent of the leuprolide is to “flood” the pituitary so that it stops producing the LH and FSH. Consequently, with no “orders” sent from the pituitary, the testis stop producing testosterone.

 

 Regards,

VG  Cool

ralph.townsend1's picture
ralph.townsend1
Posts: 359
Joined: Feb 2012

Eligard shot is given into the stomach area and the lupron is given into the butt. why would they give Eligard in the stomach area if they are same? There is less pain or none from lupron.

VascodaGama's picture
VascodaGama
Posts: 1734
Joined: Nov 2010

Ralph

My experience is from three injections of Eligard 6-month shots. I took them in different areas in the stomach and none of them caused me pain. I hope that my body responds equally in the future when I will have to return again to the medication.

In any case, subcutaneous administration uses shorter needles than the intramuscular ones, which may make a differece. Intramuscular administration is also prefered for quicker responses by the body. Eligard can be injected in other parts of the body subcutaneously, ex; in the arm.

Best

VG

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