Dec 13, 2012 - 11:39 am
I was asked, so I'll share what I know and what I experienced.
I had metastatic appendix cancer. I had major cytoreductive surgery and colon resections (yes, plural - I'm reconnected in 3 places) followed by 5 3-day cycles bi-weekly of IP chemo, starting the day after surgery.
My IP chemo cocktail contained FUDR, which is a form of 5FU, at a strength of at least 300x stronger than what they can give you systemically, since it is only minimally absorbed by the bloodstream when administered intraperitoneally.
The dose of 5FU was diluted in 2 liters of a carrier for the day one infusion. Days 2 and 3 were each of one liter of chemo solution. All was left in me to resorb - a total of 4 liters every other week. After each day's infusion, I spent an hour rolling from side to side (every 15 minutes changing side) to distribute the chemo. Most people feel bloating and perhaps nausea from the pressure from this; I had pain, and developed the very rare complication of chemical peritonitis. Thus, I had only 5 cycles of a planned 8.
With the Heated IP Chemo (HIPEC), they usually use mitomycin or oxaliplatin in the chemo bath which is circulated through your peritoneal cavity during surgery, and then drained off. It is sometimes followed by subsequent IP chemo over the next few days while you are still in the hospital (different drs have different protocols.)
The protocol I had is the only one that I know of that occurs over several months.
I do know that IP chemo is also done for Ovarian cancers, tho the chemo agents and protocols are a bit different.
I'll try to answer any questions as best I can.