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Study says Grapefruit Juice does not hurt Sutent Users

Eliezer2
Posts: 58
Joined: Aug 2012

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043256/

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

This study has been brought up a few times - it's a couple of years old. It seems to me to be a not very impressive piece of work and it could do more harm than good. It's striking that it involved only 8 subjects.

I wonder how the validity of this study stacks up against the research the sunitinib manufactureres have done.

There is considerable scope for cost savings in the administration of some drugs which are potentiated by GJ or other fruit juices (such as Seville oranges).

Moreover, the somewhat easy conclusion may cause some patients to ignore, disregard, or doubt the validity of warnings with drugs that have a marked potentiation by GJ, leading to dangerous overdoses and, the corollary, drugs where there is the anomalous attenuation effect by GJ that can lead to significantly reduced benefit from the medication, to the extent of turning possible responders into non-responders.

Max Power's picture
Max Power
Posts: 60
Joined: Sep 2012

By cost savings do you mean taking less Sutent and drinking GJ juice to get the same effect? Always wondered about that.

BTW when I was on Votrient I asked if GJ was contraindicated and they said no but they didn't want me to drink it. Why not? Because if I ever had to go onto Sutent (which I did) they didn't want to have to allow for it.

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

Basically, yes. Several papers have appeared on the subject - with some extremely expensive drugs it is possible to get the same results by drinking GJ and taking an appropriately reduced amount of the medication. This should also help to reduce the side-effects suffered.

Max Power's picture
Max Power
Posts: 60
Joined: Sep 2012

Enhanced effects without enhanced side-effects - wouldn't have thought that. What a breakthrough that would be. The whole intent of trying other drugs before Sutent was to avoid the side-effects. And cost.

A lot harder to find someone to pay for that clinical trial!

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