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MCP

smokeyjoe
Posts: 1428
Joined: Feb 2011

For those that are taking MCP, how much do you take. I've increased the amount I take and I find it to be "stick to your ribs" filling.

SharonVegas's picture
SharonVegas
Posts: 189
Joined: Feb 2012

Forgive the dumb question but what's MCP? Obviously if I don't know what it is I'm not taking it. Just curious...

steved
Posts: 836
Joined: Apr 2004

This is what ACS has to say:

Modified Citrus Pectin
Other common name(s): citrus pectin, Pecta-Sol®, MCP

Scientific/medical name(s): none

Description
Modified citrus pectin (MCP) is a form of pectin that has been altered so that it can be more easily absorbed by the digestive tract. Pectin is a carbohydrate that is made of hundreds or thousands of sugar molecules chemically linked together. It is found in most plants and is particularly plentiful in the peels of apples, citrus fruits, and plums. In modified citrus pectin, the pectin has been chemically altered to break its molecules into smaller pieces. Pectin in its natural form cannot be absorbed by the body and is considered a type of soluble dietary fiber, whereas modified pectin can be absorbed into the bloodstream.

Overview
Animal studies and a couple of uncontrolled human studies have found that MCP may inhibit the spread of prostate cancer and melanoma to other organs. However, there have been no controlled clinical studies to prove this effect in humans.

How is it promoted for use?
Proponents claim that modified citrus pectin slows or stops the growth of melanoma, a dangerous form of skin cancer, and metastatic prostate cancer (prostate cancer that has spread). Some also claim that a compound found in MCP strengthens the cancer cell–killing ability of T-cells, cells that also protect against germs.

What does it involve?
Modified citrus pectin is available as a capsule or a powder. The dose suggested by manufacturers for the powder is 5 grams (nearly a fifth of an ounce) mixed with water or juice taken 3 times a day with meals. For capsules, the suggested dose is 800 milligrams (mg) 3 times a day with meals.

What is the history behind it?
Pectin is commonly used as a gelling agent for canning foods and making jellies. It is also used widely in the production of food and cosmetics and as an ingredient in some anti-diarrhea medicines. In the past 10 years, the modified form of pectin has been investigated for anti-cancer properties.

What is the evidence?
Several animal studies found that MCP helped reduce the spread of prostate, breast, and skin cancer. Animals with these types of cancer that were fed MCP had a much lower risk of the tumor spreading to the lungs. For example, one study examined the effects of MCP on lung metastases from melanoma cells. Researchers injected mice with melanoma cells. In the mice that were also given MCP, significantly fewer tumors spread to the lungs than in the mice that did not receive the drug. When lung tumors did develop in the mice treated with MCP, the tumors tended to be smaller than those that formed in untreated animals.

These studies appear to show that MCP makes it difficult for cancer cells that break off from the main tumor to join together and grow in other organs. However, in most animal studies, MCP had no effect on the main tumor, suggesting that it may only be useful for preventing or slowing the growth of metastatic tumors in very early stages of development.

Recent laboratory studies of human and animal cells have provided information on how MCP might slow the spread of cancer. MCP appears to attach to galectin-3, a common chemical in many cells. Galectin-3 is present in abnormally high levels in many cancers and plays an important role in the growth, survival, and spread of cancer cells.

Although animal and cell studies are quite encouraging, very little information is available about whether MCP is effective in humans. In one published clinical trial, 10 men with prostate cancer were treated with MCP after standard treatment failed. In 7 of these men, blood tests found prostate-specific antigen (PSA, a marker of prostate cancer growth). Their PSA doubling time (a measure of how fast PSA goes up) improved in comparison with measurements done before taking MCP, indicating that MCP may have a slowing effect on the cancer's growth. This study had no control group (in this case, a group of men who did not take MCP), which limits the strength of its conclusions on MCP's effectiveness. It also did not measure survival or other important endpoints. However, taken with the information gained from animal studies, it suggests that MCP may have a role in reducing the growth and spread of cancer. Randomized controlled trials looking at larger groups of people must be done before any firmer conclusions can be reached.

Are there any possible problems or complications?
This product is sold as a dietary supplement in the United States. Unlike drugs (which must be tested before being allowed to be sold), the companies that make supplements are not required to prove to the Food and Drug Administration that their supplements are safe or effective, as long as they don't claim the supplements can prevent, treat, or cure any specific disease.
Some such products may not contain the amount of the herb or substance that is written on the label, and some may include other substances (contaminants). Actual amounts per dose may vary between brands or even between different batches of the same brand.
Most such supplements have not been tested to find out if they interact with medicines, foods, or other herbs and supplements. Even though some reports of interactions and harmful effects may be published, full studies of interactions and effects are not often available. Because of these limitations, any information on ill effects and interactions below should be considered incomplete.
Citrus pectin is categorized as "generally regarded as safe" by the U.S. Food and Drug Administration, When MCP is used as intended, side effects rarely occur. However, some people may experience stomach discomfort after taking MCP. There have been a few case reports in which asthma developed in people after exposure to powdered pectin. Modified citrus pectin may cause serious allergic reactions in those who are allergic to citrus fruits.

Relying on this type of treatment alone and avoiding or delaying conventional medical care for cancer may have serious health consequences.

manwithnoname
Posts: 393
Joined: Jun 2012

But I can't help but get annoyed, MCP will NEVER make it to clinical trials EVER no conspiracy theory just cold hard economic facts.

Nothing that can't be patented will EVER go to a $300,000,000 Phase3 trial.

I have GBs of data on herbal or natural treatments that wont go anywhere.

Even worse, there are dozens of 'patent free' 'off label' drugs that have passed FDA requirements with anti-cancer activity and no one will sponsor them.

Have a listen to Professor Geoff Pilkington from the UK about his experience; http://www.bbc.co.uk/programmes/b013xsm1

This is a broken system people. They push chemo that has a very poor record and anything else is forgot about or ridiculed.

smokeyjoe
Posts: 1428
Joined: Feb 2011

What I don't get is doctors not telling you something may help...something that is outside what they use as protocol. When I was going on Xeloda, I looked up stuff, says vitamin B6 may help alleviate side effects, hand foot syndrome. No mention of it until the pharmacist called me about starting up the Xeloda, I brough up Vitamin B6 to her, she asked where I had heard this, then went on that there are ongoing clinical trials, and if I wanted I could take so many vitamin B6 pills per day!!! Outside of standard protocol right now, so it's not even mentioned.

tanstaafl's picture
tanstaafl
Posts: 980
Joined: Oct 2010

4-5 grams of MCP per day, heaping teaspoon. So thick, hope that other comlplex polysaccharide sources make up the shortfall from MCP recommendations functionally. Astralugus, PSK, 4 other mushroom extracts, Biothera WGP beta glucans. Each one has its own response.

PatchAdams
Posts: 272
Joined: Nov 2011

I wrote and asked and kept the reply. I mix mine in with watered down apple sauce because the powder was just too nasty in tea or warm water. Be sure to let it sit for about 5 minutes to re-hydrate.
Dr. Eliaz MCP study

[quote]We recommend the 5 grams three times a day for 6 months to a year post the "all clear" from your doctors. Then the maintenance of 5 grams once daily.[end quote]

smokeyjoe
Posts: 1428
Joined: Feb 2011

The label on the container I got says "helps prevent the spread of abnormal cells". I suppose I need to try to spread it out over the day, which is kinda difficult at work. One study that was done on mice they found ....The data indicate that MCP might reduce mammary and colonic tumor growth and metastasis by inhibiting angiogenesis. In mammary carcinoma cells growing in the mammary fat pad of nude mice, we observed a 70.2% reduction in the mean tumor volume by 7 weeks following the oral intake of MCP (Fig. 1⇔). This was associated with a 66% reduction in blood vessels and a complete inhibition of metastasis to the lungs (Fig. 3⇔). Similarly, there was less tumor burden and metastasis in the MCP-fed nude mice into which human colon carcinoma cells (LSLiM6) were implanted than in the control mice. Metastases to lymph nodes and the liver were present in 100% and 66% of control mice versus 25% and 0% of mice fed with MCP. Someone else posted something last week re: Quercetin and MCP too if you want to take a look back and see that post.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

Interesting, gotta love mcp.

Hugs,
Pete

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