Sep 01, 2012 - 6:13 pm
There are certain antidepressants that are not supposed to be taken with tamoxifen. Here is a list of what they are if you are interested. Paxil, Prozac and Wellbutrin are the ones to avoid if you are on tamoxifen. Always talk to your doctor if you have questions or are on tamox and any of those 3.
Choosing among antidepressants
Antidepressants vary in their ability to inhibit CYP2D6 (the enzyme that converts tamoxifen into its active form, endoxifen).
Effect on CYP2D6
Safest choice if taken with tamoxifen.
desvenlafaxine (Pristiq), mirtazapine (Remeron)
Direct studies with tamoxifen are lacking, but effect on endoxifen levels should be minimal.
citalopram (Celexa), escitalopram (Lexapro), nefazodone (Serzone)
Secondary choices if above are not options.
Only citalopram and sertraline have been studied directly with tamoxifen, so risk of reducing levels of endoxifen should be weighed against benefits of antidepressants.
duloxetine (Cymbalta), sertraline (Zoloft), fluvoxamine (Luvox)
paroxetine (Paxil), fluoxetine (Prozac), bupropion (Wellbutrin)
Best to avoid if taking tamoxifen.