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Tamoxifen and Antidepressants

DebbyM's picture
DebbyM
Posts: 3294
Joined: Oct 2009

There are certain antidepressants that are not supposed to be taken with tamoxifen. Here is a list of what they are if you are interested. Paxil, Prozac and Wellbutrin are the ones to avoid if you are on tamoxifen. Always talk to your doctor if you have questions or are on tamox and any of those 3.

Choosing among antidepressants

Antidepressants vary in their ability to inhibit CYP2D6 (the enzyme that converts tamoxifen into its active form, endoxifen).

Drug

Effect on CYP2D6

Advice

venlafaxine (Effexor)

Minimal

Safest choice if taken with tamoxifen.

desvenlafaxine (Pristiq), mirtazapine (Remeron)

Direct studies with tamoxifen are lacking, but effect on endoxifen levels should be minimal.

citalopram (Celexa), escitalopram (Lexapro), nefazodone (Serzone)

Mild

Secondary choices if above are not options.

Only citalopram and sertraline have been studied directly with tamoxifen, so risk of reducing levels of endoxifen should be weighed against benefits of antidepressants.

duloxetine (Cymbalta), sertraline (Zoloft), fluvoxamine (Luvox)

Moderate

paroxetine (Paxil), fluoxetine (Prozac), bupropion (Wellbutrin)

Strong

Best to avoid if taking tamoxifen.

Pinky68's picture
Pinky68
Posts: 206
Joined: Jul 2012

This is a new SSRI, or SSNI. I think its spelled "Viibryd". We couldn't find any info with regards to Tamoxifen.Just curious if you know anything about it.
Thanks for the info! very informative
Hugs
Joyce

DebbyM's picture
DebbyM
Posts: 3294
Joined: Oct 2009

No, I don't know anything about Viibryd Joyce. Where did you hear about that? I also remember from another post about not taking paxil, prozac or wellbutrin with tamox, and if you do, it can increase your chance of a recurrence.

Pinky68's picture
Pinky68
Posts: 206
Joined: Jul 2012

My doctor who prescribes my anti-depressants said she's been having good luck with this new SSRI. She couldn't find any info in regards to taking Tamoxifen with it though. Probably because its so new on the market..My onco didn't think there have been any studies yet on taking it with Tamoxifen

As it turns out, I'm going to stay on the anti-depressants I'm taking now and have my ovaries removed...I won't have to switch antidepressants since Arimadex can be taken with the meds I'm currently on. I was just curious if anyone had heard anything about Viibryd because I didn't know it existed till a couple weeks ago.

peanutcat's picture
peanutcat
Posts: 104
Joined: Mar 2011

what is viibryd? Is it an antidepressant? I take Tomoxifen

peanutcat's picture
peanutcat
Posts: 104
Joined: Mar 2011

what is viibryd? Is it an antidepressant? I take Tomoxifen

CypressCynthia's picture
CypressCynthia
Posts: 4017
Joined: Oct 2009

Viibryd is an antidepressant and one that is not recommended with tamoxifen according to a pharmacist online: "It blocks the metabolism of tamoxifen to its active metabolite, so it's not to be taken with tamoxifen." http://dailydose.essentiahealth.org/uploads/viibryd.pdf

According to epocrates, viibryd is listed as a drug that interacts with tamoxifen and may require modifying or monitoring. I would avoid viibryd on tamoxifen unless you are unable to use a safer alternative (effexor, remeron, lexapro, etc).

Pinky68's picture
Pinky68
Posts: 206
Joined: Jul 2012

Thank-you!

Kylez's picture
Kylez
Posts: 3765
Joined: May 2009

Thanks Cynthia for making us aware of that!

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