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MGN 1703 by MOLOGEN,AG of Germany has rec'd positive

coloCan
Posts: 1873
Joined: Oct 2009

review at Phase II, no further info outside of its "prolongation of progresion free survival..." from email from stock,not cancer,site

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

can you give us something more to go than that, if you get anything else.

if its out of germany, well it must be good.

they make those sexy fast cars, so the cancer drugs must be good.

progession free survival, that means we live longer right ? why do they have to make simple concepts complex.

i know, so the doctors can charge alot to explain it to us.

hugs,
pete

steved
Posts: 836
Joined: Apr 2004

It seems that an area of interest is immunotherapy that targets TLR (toll like receptors) which are found on tumours - the idea is that agonists to these receptrs(drugs that bind to these receptors) increase antigen presentation (stuff being presented by the tumour that the body recognises as foreign) and so trigger stonger immune responses against the tumours. The aim is to undermine the ways tumours hide from teh immune system.

There is a 55 person phase 2 trail of MGN1703 in Germany inpatients with colorectal cancer with 'positive results'- I can't access anything more specific without paying for papers. Doesn't seem to have made the media much but is mentioned in Nature which is usually pretty reliable.

Anyone else access more?

steve

coloCan
Posts: 1873
Joined: Oct 2009

was mentioned on this....At one point I was writing down drugs going into trial but i no longer do that; my first hearing of MGN 1703 was in Nov 2010. Sorry i have no further info on this so i'll toss out this test for KRAS at:
fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm310899.htm

and a little technical stuff on:"Explaining the Unexplainable:EGFR Antibodies in CRC," at:
http://jco.ascopubs.org/content/30/15/1735.full

"Nature", Steve, is,as you stated, quite reliable and if you or others want to get blinded by science, try reading this:

nature.com/nature/journal/vaop/ncurrent/full/nature11282.html

"Recurrent R-spondin fusions in colon cancer"...........

If anyone comphrehends, kindly interpret for me......... steve

``

John23
Posts: 1832
Joined: Jan 2007
steved
Posts: 836
Joined: Apr 2004

Blimey- had to get my biochem book out to make sense of that one. IT is very preclinical at present but they are looking at the pathway of communication between receptors onthe outside of cells and the nucleus in the centre of cells which is done through wnt signalling ( a pathway of proteins that communicates stuff rom outside the cell to the nucleus where all the DNA sits). R-spondins stimulate this pathway and mutations in these are probably related to cancerous cell proliferation. They therefore think these may be new targets for treatments.

They haven't taken it any further to develop these new treatments but it is a totally new avenue that will be explored. I sense it is at the stage where developments will help our kids (considering all the increased risk of cancer we have passed to them) rather than us- these things take a long time to get from this to treatment stage and most don't make it.

Interesting read though- anything else you find I'm always happy to look at. Accessing recent Nature articles on line is quite tricky as they are mainly controlled.

steve

luvinlife2
Posts: 172
Joined: Jul 2012

I will ask my nat onc about this. He's very up to date on everything out of Germany.

coloCan
Posts: 1873
Joined: Oct 2009

biomedcentral.com/1471-2407/12/356/abstract

with link to full publication

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

What a team.

Smile we have a very very high collective iq.

Imagine one of us may inadvertently find a treatment that helps them and sharing the experience is our fundamental duty in my honest opinion.

Look at the negative of the statement. One of us finds out something effective, they sit on the info, they live to 100. Then they share it.

As I am 47 in a few days, that another 53 years to get to 100.

Think of the lives, the suffering saved. Our planet needs us, we have the most important understandings of life

Thanks John, you smart pants, helping out on a non tcm thread.

In case my tcm therapy needs a hand.

I got my reading ready for the weekend.

Hugs,
Pete

Ps my tcm costs 10 aid a day, about 2 Coffee in a cafe here.
What should I do. I will have my Coffee today, having it now. But not in the cafe.

coloCan
Posts: 1873
Joined: Oct 2009

http://pharmabiz.com/NewsDetails.aspx?aid=70669&sid=2

starting Phase I for Kras mutation crc.....

steved
Posts: 836
Joined: Apr 2004

It is a virus that doesn't grow in normal cells but in cancer cells with KRAS mutations it grows to the point of destroying the cell. It is in Phase 3 for some other cancers and Phase 2 in colorectal should happen pretty soon which will use it in combination with FOLFIRI and avastin.

Again a new approach to fighting cancer that opens up new hopes for those for whom the current drugs don't work.

steve

tommycat's picture
tommycat
Posts: 790
Joined: Aug 2011

I love seeing progress in cancer research. Thanks for sharing.
~Tommycat

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