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Sleep Apnea Tied to Increased Cancer Risk

Tethys41's picture
Tethys41
Posts: 1053
Joined: Sep 2010

http://well.blogs.nytimes.com/2012/05/20/sleep-apnea-tied-to-increased-cancer-risk/

Annesse
Posts: 2
Joined: May 2012

Hi Tethys41~

Very interesting! I think we can trace sleep apnea back to the PEDD pathway. Here is some information from the next addition.

Q. What causes sleep apnea?
A. As far as the autoimmune disease process is concerned, sleep apnea has been linked to low
dopamine and low acetylcholine. A study in Neurology found that patients with the lowest
dopamine levels talked and thrashed while they slept (Gilman, 2003). Those with the lowest
acetylcholine levels had the most interruptions in their breathing during sleep. This would
make sense, acetylcholine controls the throat muscles.

Also, a direct connection to cancer and sleep apnea would be elevated levels of homocysteine. The study entitled, "Endothelial cell apoptosis in obstructive sleep apnea: a link to endothelial dysfunction" found that the "impairment of endothelial-dependent vasodilation correlated with the degree of endothelial cell apoptosis." Homocysteine causes the endothelial cells to commit "mass suicide".

I just made an introductory post on the breast cancer forum. The information applies to cervical cancer as well.

Tethys41's picture
Tethys41
Posts: 1053
Joined: Sep 2010

Thanks for the information Annesse,
I know that, for me, sleep apnea probably plays a role in my original diagnosis. I just had a sleep study test and although I am normal weight for my height, I have apnea like a 280 lb. man with three chins. I knew I snored lightly, but I learned that I spend a lot of my sleeping time not breathing. Just picked up my CPAP machine today. I also have insulin resistance and I'm told that until the sleep apnea is resolved, that is not going to correct. I can attest to that. I've not eaten sugar in over a year and am eating a very low carb diet. If it weren't for the apnea, this should have resolved long ago.
As far as dopamine and acetylcholine, I wonder about the information regarding low levels and sleep apnea. I'm on supplements for both. I might beleive the acetylcholine could be low, as I've only been taking that supplement for about a month. But the dopamine supplement I've been on for two years.
Thanks again for posting.

Tethys41's picture
Tethys41
Posts: 1053
Joined: Sep 2010

Just double posting

Annesse
Posts: 2
Joined: May 2012

Sorry~Double Post

carolenk's picture
carolenk
Posts: 909
Joined: Feb 2011

Thanks for posting! The info on sleep apnea was completely new to me & very much appreciated. I find these discussion boards to be a fountain of cutting edge information.

Please share your thoughts with us anytime. I hope that you are winning your fight against cancer.

Thanks, again, new friend.

Kristin1
Posts: 2
Joined: May 2012

Hi Tethys41, I think homocysteine may be what is responsible for your sleep apnea. Homocysteine will also cause insulin resistance,which you said you also had. I just joined, so not sure about posting links, but here is the title to a study from diabetesjournals.org "Fasting Plasma Homocysteine Levels in the Insulin Resistance Syndrome."

Homocysteine is also linked to cervical cancer. Here is the title of one such study.

"Homocysteine levels are associated with cervical cancer independent of methylene tetrahydrofolate reductase gene (MTHFR) polymorphisms in Indian population."

The lack of dopamine and acetylcholine are also directly linked to the elevated homocysteine, so it does all fit together.

Kristin1
Posts: 2
Joined: May 2012

Here is the title to a study on the elevated homocysteine in ovarian cancer.

Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells

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