Feb 06, 2012 - 5:35 pm
The Gynecologic Oncology Group (GOG) held its 84th Semi-Annual Meeting on Januray 26-29, 2012 in San Diego, CA.
Presented last summer, in the first head-to-head clinical trial comparing gene expression patterns (molecular profiling) with personalized cancer cytometric testing (functional profiling or chemosensitivity testing), personalized cancer cytometrics was found to be substantially more accurate.
Four different genes were included in the molecular part of the study. The four genes were selected as those which researchers believe to have the greatest likelihood of accurately predicting individual patient response to specific anti-cancer drugs.
Although this was the first head-to-head, the accuracy levels found in this trial for personalized cancer cytometric testing were strikingly consistent with those doented in dozens of previous studies, published by respected cancer researchers around the world. In those studies, as in this one, extremely high levels of correlation (in other words, high levels of test accuracy) were found for personalized cancer cytometrics.
Source: Arienti et al. Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy. Journal of Translational Medicine 2011, 9:94.
It was hoped that something like this study would be proposed at the semi-annual GOG meeting. Perhaps a good three-armed clinical trial: physician's choice vs molecular profiling vs functional profiling?
I understand this issue has been an ongoing saga for some years now. The question that should be addressed is an across the board assessment of the relative accuracy of different endpoints. They should answer all the questions at once, not one followed by another. I hope we do not have to wait until the summer ASCO meeting to find out.