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Found this in another forum--- low iodine diet not important ! What do you think ?

MarinMark
Posts: 139
Joined: Aug 2011

Lack of Association between Urinary Iodine Excretion
and Successful Thyroid Ablation in Thyroid Cancer
Patients

Hernan P. Tala Jury,* Maria Grazia Castagna,* Carla Fioravanti, Claudia Cipri,
Ernesto Brianzoni, and Furio Pacini
Unit of Nuclear Medicine (E.B.), Macerata Hospital, 62100 Macerata, Italy; and Section of Endocrinology
and Metabolism, Department of Internal Medicine, Endocrinology, and Metabolism and Biochemistry
(H.P.T.J., M.G.C., C.F., C.C., F.P.), University of Siena, 53100 Siena, Italy

Background: Low-iodine diet is prescribed before 131I administration in patients with differentiated
thyroid cancer, although no study has properly quantified its clinical benefit.
Objective: Our study aimed to evaluate the association between urinary iodine excretion (UIE) and
131I ablation by correlating UIE with the rate of successful ablation.
Patients: We retrospectively studied 201 differentiated thyroid cancer patients who had received 131I
therapy and posttherapy whole-body scan (WBS) for remnant ablation after either thyroid hormone
withdrawal (THW group, n125) or recombinant human TSH (rhTSH group, n76). The outcome of
thyroid ablation was assessed using two different criteria: no visible uptake at control WBS 8–12
months after ablation or no visible uptake plus undetectable stimulated serum thyroglobulin (Tg).
Results: According to the criterion of no visible uptake, 84.6% of the patients were successfully
ablated, with no significant difference between THW and rhTSH groups. Mean UIE at the time of
ablation was 132160g/liter, not significantly different between patients of theTHWand rhTSH
groups. There was no significant difference in UIE between ablated or nonablated patients both
in the whole group and the rhTSH or THW groups. According to the criterion of no visible uptake
plus undetectable stimulated serum Tg (in anti-Tg negative patients) at control WBS 8–12 months
after ablation, UIE was not significantly different in ablated and nonablated patients.
Conclusions: Our study indicates that the body iodine content is not an important determinant of
thyroid ablation, when preparing the patients with either THW or rhTSH. (J Clin Endocrinol Metab
95: 230–237, 2010)

alapah's picture
alapah
Posts: 258
Joined: Oct 2009

As my subject line says, my take on this is why not do the Low Iodine Diet - it certainly won't hurt or hinder the efficacy of RAI and if it could be of help, why not do it. It's not too hard and you don't need to do it for very long. Small price to pay to potentially improve the power of the RAI.

amorriso
Posts: 186
Joined: Oct 2010

And I think this study can also help those of us who may accidently have something on the diet that isnt allowed. We dont have to panic and think oh no - the RAI is not going to work because I had a piece of cheese.....

Cheers

Andrea

MarinMark
Posts: 139
Joined: Aug 2011

The study is referring to ablation, not necessarily metastases. And this was an Italian population, not USA. Think there were a few other problems. Will ask around.

MarinMark
Posts: 139
Joined: Aug 2011

A low iodine diet cannot hurt treatment, so I plan on doing it at least two weeks.

teamwink
Posts: 97
Joined: May 2011

My doc originally said no to the LID, then changed her mind and said to do it. I was under the mindset that I don't want to do this again, so I figured I'd do as much as I possibly could do to prevent another round of this junk. Therefore, I went LID full force - I didn't want to look back and think I should've done it and didn't. Many docs argue against it, particularly if you use Thyrogen and don't withdraw from your meds.

MarinMark
Posts: 139
Joined: Aug 2011

Teamwink---- argue against what ? Not using the LID ? How could anyone argue against it if it cannot to any harm ? I know Docs who are adamant it be done for over two weeks.

teamwink
Posts: 97
Joined: May 2011

Yes, against the LID - I agree that if it doesn't hurt, why not try it. It wasn't delicious, but I definitely wanted to ensure as much tissue was out of my body :( I went LID full force

MarinMark
Posts: 139
Joined: Aug 2011

I've seen several doctors. One of them recommended the diet for four weeks. Think I'll do that.

alapah's picture
alapah
Posts: 258
Joined: Oct 2009

which is more than they say but I had a lot of iodine in my system from contrast used in a CT scan. i figured why not do the most i could to help get rid of it all. i admit though that the diet got very boring by the end. however, in the grand scheme of things it was no grand sacrifice being on the LID and now it's kind of a distant memory. contrast that with some of the issues other cancer patients face and the LID is not that big of a deal. good luck MM! by the end you may be craving dairy and all sorts of things. i never eat it, but by the end i was craving fried chicken - which i was able to havei not long after the RAI.

nasher
Posts: 507
Joined: Apr 2010

as far as i can tell the article is based on

withdraw from thyroid hormone (THW) and
thyrogen [recombinant human THS] (rhTSH)

the line
Background: Low-iodine diet is prescribed before 131I administration in patients with differentiated thyroid cancer, although no study has properly quantified its clinical benefit.

is just that background its not based on if you did LID or not study on it

what it dose show is thet
THW and rhTSH both work the same

sunnyaz
Posts: 582
Joined: Oct 2010

That's what I got out of it too nasher. I couldn't agree more with teamwink as well. Even thought the LID isn't the fun to do, at least it gave my cells a fighting chance to take up the RAI and be eliminated. Therefore, I take the "it can't hurt" approach.
sunnyaz

sunnyaz
Posts: 582
Joined: Oct 2010

That's what I got out of it too nasher. I couldn't agree more with teamwink as well. Even though the LID isn't fun to do, at least it gave my cells a fighting chance to take up the RAI and be eliminated. Therefore, I take the "it can't hurt" approach.
sunnyaz

CLRRN's picture
CLRRN
Posts: 126
Joined: Jun 2010

The logic and science makes sense-LID to make your body crave iodine and in this case, laced w/radioactive material...LOL It's can't hurt and there is more information out there about LID then not. I started the LID today...we spent a fortune at the grocery store LOL.

My ENDO gave me instructions from NIH and they differ slightly from thyca.org. Trying to find a happy medium between the two.

I'm right there with you....."it can't hurt" :)

MarinMark
Posts: 139
Joined: Aug 2011

I'm relying mostly on the Low Iodine Cookbook in electronic form. Tonight I had friend squash with basil and onions.

sunnyaz
Posts: 582
Joined: Oct 2010

Sounds yummy!

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