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A New Era for Glioma

I_Promise's picture
I_Promise
Posts: 210
Joined: Aug 2011

Dear all,

if you are reading this message, then it means that you either have brain cancer or your love one does. Either way I am so so sorry.

I did a websearch regarding ONCOLYTIC therapy and gliomas.For the scientifically inclined:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720101/

The theory is that viruses invade cells. We can and we have created viruses that only kills tumor cells and not the normal brain.

It is all there. It is maddening to me how long all this research takes. Some people do not have five years to wait. Stop doing it on mice already. Do it on humans. Or lets stop playing with phase 1 and 2 (to prove that the virus is safe... when someone is dying, you can rool the dices). Lets do phase 3.

I truly believe the cure for glioma is out there. Between all the oncolytic virus therapy and gene therapy.

Anyone out there has participated in an oncolytic virus therapy? The HSV clinical trial?

Let me know. Thank you.

Julia

JPoole's picture
JPoole
Posts: 4
Joined: Sep 2011

Julia

Thank you for posting this. It makes me feel good to know that people are actually working on a cure.

James

a018528
Posts: 4
Joined: Sep 2011

I have just recently discovered for sure what I have know I had for over 4 years, oligodendroglioma. During my research to find out all I can about this brain tumor, I found this article concerning gene mutations studies conducted at Johns Hopkins and Duke University. It sounds like good news, but, like I read on this post earlier, it seems that research takes a long time. Still take the time to update your library with this:

http://www.dukehealth.org/health_library/news/elusive-gene-mutations-found-for-malignant-brain-tumor?utm_source=dukehealth.org&utm_medium=rss&utm_campaign=RSS_news

David

I_Promise's picture
I_Promise
Posts: 210
Joined: Aug 2011

Dear all,

David: I check out your link. I agree it is encouraging to see more and more knowledge about the MONSTER.

I send my sister's tumor to various places (Carris Life, Duke and Hopkins) to get both a molecular analysis and cytology. My hope is that one day this info can be useful to her.

There is a cure. The only thing is I don't know how long it is going to take.
The whole goal of phase 1 or 2 clinical trial is " is this dug/vaccine/virus safe" not if it works. So I don't want my sister participating in any of them just yet. Phase 3 is to compare it to the standard regimen.

It is tough to read literature. You cannot get discouraged.

For example:

The New castle Virus VACCINE in Germany pilot study: (for recurrent GBM)

"

In a nonrandomized study, 23 patients were vaccinated and compared with nonvaccinated controls (n = 87). Vaccine was prepared from patient's tumor cell cultures by infection of the cells with Newcastle Disease Virus, followed by gamma-irradiation, and applied up to eight times.
Forty-five percent of the controls survived 1 year, 11% survived 2 years, and there were no long-term survivors (≥ 3 years). Ninety-one percent of vaccinated patients survived 1 year, 39% survived 2 years, and 4% were long-term survivors."

I am thinking... what the &%$*^%$^$? only 4 % long term survivor? I want at leat 80%!!!

But then I remind myself that this is a new field. Only 10 years of seriously doing gene therapy experiments.

It gives me the urge to create my own lab and do my own experiment (just kidding).

Peace,

Julia

a018528
Posts: 4
Joined: Sep 2011

Hi Julia,

Thanks for the reply and I agree with you that the answers to our problems seem mighty slow in coming, especially when we look each day in the face not knowing what to expect.

But let me know when you start your lab so I can cheer you on.

Let me say, I know what the statistics say can be overwhelming, but, we don't live by statistics. All my life I have had "episodes" of dizziness, fainting or seizures. The most pronounced seemed to end when I was 14 yrs. old. I still have the "dizzy headiness" at times and I am now 55 yrs. old. In 2007 I was found to have a 4cm Glioma in the right parental lobe. It was found on a CT scan after fainting and hitting my head. It is still not clear if that is the cause of all the episodes. However, this summer, I began having seizures on my left side and was hospitalized for a biopsy of the now 6cm Glioma. It turned out to be a non-malignant Oligodendroglioma. As a side-note, a PA at my regular Dr.s office diagnosed an inner ear infection as the cause of the pressure causing the seizures. After 10 days of antibiotics, WOW, no more seizures. Seems most of the doctors overlooked it.

This was my 2nd time dealing with cancer. Melanoma surgery in 1999 and now a brain tumor.

Excuse my long windness, but, I say all that to say this, don't let statistics scare you. The smartest doctors can't determine what God or our bodies are capable of. 55 years is a pretty good statistic, don't ya think!

Looking forward to getting your lab results!

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