Farewell FOLFIRI....

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kuastoi
kuastoi Member Posts: 63
in Colorectal Cancer #1
Movin' on these days - I've chewed through FOLFOX, avastin, FOLFIRI and ertbitux now, on to the clinical trial scene.

I'm being screened at MGH for the RAD001/AV-951 trial. RAD001 is everolimus, an agent that is already approved for renal cancer and attacks the m-TOR pathway. the AV-951 is a VEGF pathway agent, much like avastin. Both attack the blood vessel formation and tumor growth - so we'll see what happens here. Hope to start on April 4th if all scans and blood work are acceptable.

Anyone else on the protocol or something similar? It is offered at Mass General and Dana Farber as far as I know, I have also seen some references to some RAD001 trials at MD Anderson too (but I think they are single agent trials)

Tom

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  • taraHK
    taraHK Member Posts: 1,952 Member
    #2
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    good luck
    Hi Tom,

    Sorry to hear that those options haven't worked out for you -- but glad that you have some clinical trial options open to you.

    I'm on Xeliri + Avastin at the moment. Seems to be working out OK for me right now but Erbitux isn't an option for me (yes, I'm a mutant) and I am certainly keeping my eyes peeled for future options -- which appear somewhat limited for me.

    So I am very interested to hear about the clinical trials you are exploring. I am sorry I have nothing to add on those but I do wish you all the best -- and would be so grateful if you could keep us posted.

    Tara
  • kanniek1
    kanniek1 Member Posts: 2
    #3
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    How to handle stage 4 colon cancer
    How long have you been diagnosed with stage 4 colon cancer? Am currently on treatment for same.How are you feeling?
  • kuastoi
    kuastoi Member Posts: 63
    #4
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    kanniek1 said:

    How to handle stage 4 colon cancer
    How long have you been diagnosed with stage 4 colon cancer? Am currently on treatment for same.How are you feeling?

    Thanks for the support...
    I am off to Boston in the AM for the final screening - hope to start the trial next week if I am eligible. As long as I do not have any mets in my noggin I will be accepted I think. Should be OK, my wife has been saying I have nothing up there for years.....after chemo I am beginning to agree.

    As for my history - I just passed my 2 year anniversary of being diagnosed. I feel pretty good generally - a little tired and I've got some neuropathy issues from the old FOLFOX, but I bike on my trainer 10 miles a day despite the issues. Looking forward to warmer weather and outdoor activities...

    Tom
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #5
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    kuastoi said:

    Thanks for the support...
    I am off to Boston in the AM for the final screening - hope to start the trial next week if I am eligible. As long as I do not have any mets in my noggin I will be accepted I think. Should be OK, my wife has been saying I have nothing up there for years.....after chemo I am beginning to agree.

    As for my history - I just passed my 2 year anniversary of being diagnosed. I feel pretty good generally - a little tired and I've got some neuropathy issues from the old FOLFOX, but I bike on my trainer 10 miles a day despite the issues. Looking forward to warmer weather and outdoor activities...

    Tom

    goodluck on the trial
    hi tom,

    just give the trial your best shot, hope the chemo is not to horrendous.

    I hope it payoff you and all who follow.

    god bless you,

    Pete

    ps you shoudl join my walking post
    10 miles a day is awesome.
  • kuastoi
    kuastoi Member Posts: 63
    #6
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    pete43lost_at_sea said:

    goodluck on the trial
    hi tom,

    just give the trial your best shot, hope the chemo is not to horrendous.

    I hope it payoff you and all who follow.

    god bless you,

    Pete

    ps you shoudl join my walking post
    10 miles a day is awesome.

    Back from Boston
    Crossing my fingers - hope to hear from then in next few days as to my eligibility for the trail. If OK will star on the 4th. Back on the bike in the AM

    Tom

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