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New Chemotherapy Drugs

New Chemotherapy Drugs

I read continually on the forum, about "new" chemotherapy drugs,
yet all the research I've done can not locate one chemotherapy drug
that has been newly patented and released.

I'm no slouch when it comes to research, it's "brought home the bacon",
so to speak, but all I can find, are reformulated (and re-named)
drugs that have been around for a long time, some over 20 years.

Many chemotherapy drugs that have entered into the list of "soon-to be"
expired patent drugs, are quickly reformulated and re-named, and
re-issued, to provide continued profits by the company that owns the patent.

Avistan (bevacizumab) for instance, has been around since 1995.
Not one thing about the basic composition has been changed in all
these years, yet so many individuals seem to think it's something new!

If anyone at all can provide me with the name of a "new" chemotherapy
drug that has been patented and released fairly recently, I would greatly
appreciate it!

My quest for knowledge never seems to deplete!

Thanks.

Comments

PhillieG's picture

What's "New"?

So saying that there's been nothing "new" in TCM for close to 4000 years is equally as valid, true?
Just because some of the drugs used in chemo were discovered years ago, it doesn't discount the fact that there have been new ways to administer and combine them that ARE effective in the treatment (and cure) of some cancers.
Just something for people to keep in mind.
Old doesn't mean useless...
:-)
Be well,
-phil

Missing the point?

Re:
"What's "New"?
.........So saying that there's been nothing "new" in TCM for
close to 4000 years is equally as valid, true? Just because some
of the drugs used in chemo were discovered years ago......."

Traditional Chinese Medicine has -not- been making any claims
that "a new herb or treatment" has been discovered that will
do what a previous herb or treatment did not.

The discussion is regarding misleading claims from medicinal
manufacturers that they are releasing a "new drug" that will help
with a problem that a former drug was used for -- when the drug
in question is actually the same drug with a newly licensed name.

The publishing of "forward looking statements" to encourage investors
to buy into a product, has been used for years and most investors
understand the use of misleading statements.

Using the same type of misleading dialog to encourage individuals
(and their physicians) that are fighting for their lives, can be considered
a disgrace.

We all look forward to a new drug or product that might save our
lives; To be mislead into thinking that one has been found when
all it is, is a renaming of an old drug, is in my opinion nothing
short of horrible. It is akin to the "bait and switch" dialog of a
common scam artist.

Here's hoping a real medicine comes along!

Best of health,

John

PhillieG's picture

Just Pointing out Semantics John

And using "Geometric Logic..."
I would love to see words like "always", "never", "all", and many others removed from the English language.
Blanket statements are rarely true (notice I didn't use the word "never"?)

I do agree that there are so many drugs out there. Many for things that I think are often bogus. Like the latest shingles scare stuff. Of course most of us had chicken pox so now big pharm wants people to take Shingle-Away or some crap. I too get frustrated/pissed off, etc.

Some advances HAVE been made though in dealing with cancer. You can spin it, or play semantics all you want but there are treatments that weren't there before and are here now.

I'm surprised it took you so long to see my post!
I don't really visit my expressions pages too often either.
Let's hope they solve this puzzle.
Be Well
-p

i am a care giver, my 1st post, i hope my post 2 u is ok

Hi John23, I like this from your profile (see below) only because it helps me from crying (almost) at my desk at work. And I agree w/ your post, above ("It's far better to eat a well-rounded diet, complete with meat,veggies, fruit, fish, etc etc... You'll be healthier and happier ..... ").

I wish there was a day to day diary of what i can expect, in helping me to know how to give the best care possible to my partner and what i should provide (or not) concerning knowledge of his newly diagnosed stage iv colon cancer (Metastatic Colorectal). It has metastasized to his liver, lungs and adrenal gland. His cancer was hidden pretty good, he has been told he has a rare cancer.

He had his 1st chemo last week Tuesday, had a tuff weekend (this past weekend) and he got the chemo via a port. He has a appetite but has lost a lot of weight. The nausea seems to be the toughest grind, currently. But with all this said we seem to be coming around the 1st tough corner of this disease. The other corners we glided through (mentally and physically) with ease due to my partner’s want to fight.

New (2011):
After surgery to repair an intestinal blockage in January of 2011,
I had been made aware that my diagnosis in 2006 was as a
"stage 4" colon cancer, not as a "3c" as only one Oncologist
had suggested at the time. It had been noted that in 2006,
I had spots on both lungs, liver, and positive testing lymph
nodes remote from the colon

My ? for you John (and others?!)

1. Does a rare cancer mean aggressive?
The actual cancer Metastatic Colorectal was diagnosed two weeks after Thanksgiving 2011, at Christmas due to 100% blockage he had his colon anastomosis(?) and sailed through that surgery. We dont know the exact kind Metastatic Colorectal because the tumor is buried very deep. He was staged @ stage iv colon cancer (Metastatic Colorectal) at the beginning of Dec 2011 because of the metastasize in the liver, one of the 7 spots seen by an image was biopsied (positive) therefore diagnosis is metastasize colorectal cancer. Dec 23 it had spread to the lung and now we know it is in the adrenal gland too. They see that this is a type of metastasize colorectal cancer and wont operate on the colorectal cancer/tumor. There is no need for that surgical procedure it would probably create more problems than just getting an answer of what kind of colorectal cancer he has.

2. My specific question here is... is there a typical chemo hangover?
His chemo is for quality of life. I am having a tuff time w/ chemo, I have questions as the caregiver. His appetite is good/great, just the nausea can be VERY tuff. We have the pain under control. What I am asking is there more nausea, and more “just crappy feeling” after a couple days after getting the chemo (and that this will goes slowly away, get better?). I feel all the meds are working but slowly, we have also seemed to have figured out what anti nausea meds work, what pain meds work , etc., in referring to what to give at what time and what works best.

3. What would you say to a care giver, or what do you say to your care giver in regards to how best help to you.
He had colonoscopy, bronscopsoly, etc, over a year and a couple of months ago, before his diagnosis, all came up clear.

4. The cancer in general reduces the person's weight?

I am a full blown AIDS survivor of 15+ years, I have been lucky that my opportunistic infections have been minimal. I want to know what do u think of the new inbitors e.g. multi-kinase inhibitor (and ones maybe to follow) like Regorafenib for crc. When I was diagnosed w/ AIDS at that time treatment was nil, I am to naive for my partner and I to believe a new drug could come out in the next 5 to 10 years for his disease (as it has for hiv/aids). And is there a good reason to hang on (as I did) and fight (against all odds?). Many of your posts remind me (over the many years) of my success (herbs!) and downers (to provide continued profits by the company that owns the patent (this happens in HIV/AIDS drug arena too)).

Thank you for putting your info out here in this forum, it is very helpful to my mind, body and spirit. I want to continue to give all kinds of help to my partner and ANY advice is appreciated. My thoughts of care and help are put out to you over this internet. I really appreciate you putting your info in this forum. I greatly helps, at least me.

Thank you,

Michael Mulheran

stayingcalm's picture

Ok, how about these, in trials still (I think)

MK-2206 (Merck)
XL-184 (Exelixis)
Crizotinib (Pfizer) [PF-1066]
Lucanix (NovaRX)
Pertuzumab (Genentech)

As I said, these are in trials...I've got my eye on Crizotinib, hope it makes it through the approval process!

Crizotinib

It's a reformulated compound, and it's showing promise for small cell lung cancer,
but it's limited to only about 2-7% of the cancer victims that have that type.
See: Crizotinib in ALK-rearranged cancer mutations

You have to keep in mind, that the "success rate" is measured in
"gained time" from the date of expected death. They call that the
PFS rate (Progression-Free Survival rate), and for this drug, so far,
it is a mean of about 6 months. Not exactly a big "whoopee",
unless there was something really important that I wanted to
see during that extra 6 months......

I didn't go through the other compounds, but will, if you'd like?
I stopped getting too excited with all of it, after about the 365th
one. The manufacturers take compounds that are about to reach
their patent expiration date, and changer the mix just enough to
get another license.

I do get more excited with ones like "Trovax", that was designed to
use the immune system exclusively, to fight cancer. It was like the
"Salk Vaccine" for cancer! It's too bad about what the big guys
did to that... oh well...

I know I sound like a "doomsayer", and very negative, but there
has to be a conscious effort to remain in reality and not get too
caught up in pharmaceutical hype.

If you have a weed taking over your lawn, and you use a toxic
chemical on the entire lawn to kill that weed, you'll damage the
entire lawn. That stupid weed will likely grow back before the
good grass does. If you do that often enough, all you'll have left
is useless dirt.... (and maybe some weeds).

If you managed instead, to help the good grass grow and flourish,
it might eventually crowd out the weeds, or at least prevent the weeds
from taking over.

All we are, is a big lawn. Yank a weed out, and eat the thing.

(haha)

Stay sane, you -will- get better! Trust me. Just use your instincts
to find the right path.

Be well.

John

New Chemotherapy Drugs

Hi John,

Well do new targeted therapies that are approved in China count?
There is a new drug that has been recently approved for cancer patients in China called BRM-SJS. This drug has TCM compounds as well. I know of the drug because I have met the inventor of the drug Dr. Wang. Anyway I this is a new cancer drug that is available now to patients in China.

Arkangel -

BRM-SJS was actually introduced prior to 2003:

"Objective: To investigate the antitumor activity and the
mechanism of BRM-SJS on breast cancer cells. Methods: Flow
cytometry, DNA agarose gel electrophoresis and other techniques
were used to study the in vitro and in vivo inhibitory effect on
BcaP-37 cells by BRM-SJS. Results: BRM-SJS showed an inhibitory
rate of 33.8% on in vivo transplanted tumor (P<0.05, compared
with control). The flow cytometry analysis of BRM-SJS treated
BcaP-37 (2.5 μmol/L, 5 μmol/L, 10 μmol/L for 48 h and 72 h)
revealed typical sub-G1 peak. The specific DNA Ladders were
exhibited with BRM-SJS BcaP-37 cells treated. Conclusion: BRM-SJS
has marked antitumor activity on BcaP-37 and its inhibitory
effects on tumor were realized by both induction of apoptosis and
necrosis of the tumor cells."

From: Brm-sjs Induces Programmed Cell Death In Bcap-37 Human Breast Cancer Cells

In 2004:
"Antitumor effect and apoptosis induction in human cancer cell
lines by BRM-SJS.:Ai Zheng. 2004 Nov;23(11 Suppl):1386-9.
Chinese.Liu ZY, Wang ZG, Liu XJ, Tian HM, Surapol , Na DY, Zhang
YF, Zhang W.Cancer Institute of Chinese Academy of Medical
Sciences and Peking Union Medical College, Beijing, P.R.China.

BACKGROUND & OBJECTIVE: It had been observed that BRM-SJS had
antitumor effect in our clinical practice. This study was
designed to investigate the antitumor activity of BRM-SJS, and
mechanism of its action. METHODS: In vitro antitumor experiments
with MTT method, meanwhile cell morphology, flow cytometry, and
agarose gel electrophoresis were performed for determining
apoptosis in several tumor cell lines. RESULTS: BRM-SJS had
antitumor effects on human Suzhou human glioma (SHG-44), breast
carcinoma (MCF-7), and human pancreas carcinoma (PANC1) in vitro,
the IC50 values of BRM-SJS were 0. 299 mg/ml, 1.853 mg/ml and
9.416 mg/ml respectively. At the 2. 5 mg of BRM-SJS on SHG-44 and
MCF-7, marked morphological changes, including cell shrinkage and
condensation of chromosomes, were observed with electric
microscope. The increase of apoptosis in SHG-44 and MCF-7 cells
treated with BRM-SJS extracts 0.625 -2.5 mg for 14 -48 h was
observed by Annexin-V/PI flow cytometry analysis. Agarose gel
electrophoresis of DNA from SHG-44 and MCF-7 cells treated with
BRM-SJS extracts 1.25 -5 mg for 24 h or 48 h showed marked DNA
Ladder pattern. CONCLUSION: Antitumor activity of BRM-SJS may be
related with inducement of apoptosis of tumor cells. "
From: http://www.mdidea.com/products/new/new088research.html

More:
Beijing Clinical Cancer Gene Research Center

Ironically, one of the herbs in the list I've posted, contains one
of the ingredients of this compound. The herbs have been used
for thousands of years, but only are being recognized by western
medicine as being "viable" today.

In my opinion:
There are better ways to fight cancer, than the barbaric chemical methods
being used by western medicine that can often do more damage than good.

Thanks for the input, I appreciate it!

John

HeartofSoul's picture

These are the latest chemo's

These are the latest chemo's to be released

Tasigna

Tasigna is the brand name for the generic medication, nilotinib. It was originally approved by the FDA in 2007, but was approved for a new use on June 17, 2010. Tasigna is used for the treatment of patients who have been recently diagnosed with Philadelphia-chromosome-positive chronic myeloid leukemia. This is an oral medication which patients take twice daily without food. Tasigna belongs to a class of drugs called kinase inhibitors which help to deactivate enzymes that lead to uncontrolled cancer growth.

Jevtana

Also approved by the FDA on June 17, 2010 is Jevtana for prostate cancer. It is also known by the generic name cabazitaxel. Jevtana is used along with the steroid, prednisone, to treat men with advanced prostate cancer that has spread and did not respond to previous treatment. It is an injectable medication known as a microtubule inhibitor that interrupts the function of cancer cells. Jevtana is a powerful chemo drug that can cause low white blood cell counts which means frequent monitoring of patients treated with this medication.

Tykerb

Tykerb received FDA approval in late January 2010. Also known by its generic name, lapatinib, Tykerb is used for treatment of patients with HER2-positive breast cancer that has spread. The initial approval is for women who have already experienced menopause. Tykerb is combined with letrozole or capecitabine to help women whose breast cancer responds to hormone-blocking treatment. It is an oral medication that has been associated with liver problems during treatment.

Provenge (sipuleucel-T); Dendreon;
For the treatment of hormone refractory prostate cancer, Approved May 2010

2009

The U.S. Food and Drug Administration today approved Rituxan (rituximab) to treat certain patients with chronic lymphocytic leukemia (CLL), a slowly progressing blood and bone marrow cancer.

Rituxan, an anti-cancer drug, is intended for patients with CLL who are beginning chemotherapy for the first time and for those who have not responded to other cancer drugs for CLL. Rituxan is administered with two other chemotherapy drugs, fludarabine and cyclophosphamide.

Votrient (pazopanib); GlaxoSmithKline; For the treatment of renal cell carcinoma, Approved October of 2009

Istodax (romidepsin); Gloucester Pharmaceuticals; For the treatment of cutaneous T-cell lymphoma Nov 2009

Cervarix [Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant; GlaxoSmithKline; For the prevention of cervical cancer and cervical intraepithelial neoplasia caused by HPV types 16 and 18 Oct 2009

Avastin (bevacizumab); Genentech; For the treatment of renal cell carcinoma July 2008

Arzerra (ofatumumab); GlaxoSmithKline; For the treatment of chronic lymphocytic leukemia, Approved Oct 2009

Afinitor (everolimus); Novartis; For the treatment of renal cell carcinoma, Approved March 2009

Vectibix released 2006
Generic Name: Panitumumab

Drug Type:
Vectibix is classified as a "monoclonal antibody" and "signal transduction inhibitor" by binding to epidermal growth factor receptors (EGFR). To treat advanced colon cancer

Alimta® released 2004
Generic name: Pemetrexed
Alimta is the trade name for the generic drug name Pemetrexed. In some cases, health care professionals may use the trade name Alimta when referring to the generic drug name Pemetrexed.

Drug type: Alimta is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "antimetabolite". To treat non small cell lung cancer non squamous

Drug Type: Tarceva 2004
Genentech, OSI Pharmaceuticals; For the treatment of advanced
refractory metastatic non-small cell lung cancer

Targeted therapies
As researchers have come to learn more about the inner workings of cancer cells, they have begun to create new drugs that attack cancer cells more specifically than traditional chemotherapy drugs can. Most attack cells with mutant versions of certain genes, or cells that express too many copies of a particular gene. These drugs can be used as part of primary treatment or after treatment to maintain remission or decrease the chance of recurrence.

Only a handful of these drugs are available at this time. Examples include imatinib (Gleevec®), gefitinib (Iressa®), erlotinib (Tarceva®), sunitinib (Sutent®) and bortezomib (Velcade®). Types of immunotherapies include:

Monoclonal antibody therapy (passive immunotherapies) -- rituximab (Rituxan®) and alemtuzumab (Campath®)

I appreciate the input!

Unfortunately, I'm looking for new chemotherapy drugs to
research, and all those listed are fairly old products:

----------------------------

Tasigna / nilotinib:
It was approved as Tasigna in the USA and the EU for
drug-resistant chronic myelogenous leukemia (CML)[2].
In June 2006, a Phase I clinical trial found nilotinib, also known
by its clinical code AMN107, has a relatively favorable safety profile
and shows activity in cases of CML resistant to treatment with
imatinib (Glivec), another tyrosine kinase inhibitor currently
used as a first-line treatment.[3] In that study 92% of patients
(already resistant or unresponsive to Glivec) achieved a normal
white blood cell counts after five months of treatment.[4] The
drug carries a black box warning for possible heart complications.

Jevtana / cabazitaxel / Paclitaxel / TAXOL:
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It
was discovered in a U.S. National Cancer Institute program at the
Research Triangle Institute in 1967
when Monroe E. Wall and
Mansukh C. Wani isolated it from the bark of the Pacific yew
tree, Taxus brevifolia and named it taxol. When it was developed
commercially by Bristol-Myers Squibb (BMS) the generic name was
changed to paclitaxel and the BMS compound is sold under the
trademark TAXOL.

Tykerb / lapatinib:
A 2006 GSK-supported randomized clinical trial on female breast
cancer previously being treated with those agents (anthracycline,
a taxane and trastuzumab) demonstrated that administrating
lapatinib in combination with capecitabine delayed the time of
further cancer growth compared to regime that use capecitabine alone.

Provenge (sipuleucel-T); Dendreon;
Journal of Clinical Oncology, Vol 24, No 19 (July 1), 2006: pp. 3089-3094
© 2006 American Society of Clinical Oncology.
DOI: 10.1200/JCO.2005.04.5252
Placebo-Controlled Phase III Trial of Immunologic Therapy with
Sipuleucel-T (APC8015) in Patients with Metastatic, Asymptomatic
Hormone Refractory Prostate Cancer

Rituxan / rituximab:
Rituximab was developed by IDEC Pharmaceuticals (formed in 1986
by biotech pioneers Ivor Royston and Howard Birndorf).
[1] Based
on its safety and effectiveness in clinical trials,[2] rituximab was
approved by the U.S. Food and Drug Administration in 1997 for
B cell non-Hodgkin lymphoma resistant to other chemotherapy regimens.

------------------

Some of the above compounds have been "reformulated" from older
patents, but it is quite a job to post all the data here; It involves parsing
chemical properties.

I'm looking for brand new compounds, but all I've been able to locate
are similar to what has been posted here.

Many thanks again.

John

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