It has been a while since my last visit to this site. My wife was diagnosed with Anaplastic Astrocytoma Grade 3 in 2006 - surgery, radiation and temodar. Surgery again in July 2009 followed by Temodar again. Since then she has only been getting worse. She now has a new tumor that is inoperable (too deep) and has spread over a large area (crossed over from right side of brain to left). They are labeling this tumor GBM (due to the rapid growth I am guessing). They stopped the Temodar as it is no longer working and started Lomustine (chemo) which on its own has little chance of working at this point. They want to treat her with Avastin along with the Lomustine. Lomustine is taken every 6 weeks and the Avastin injection would be every two weeks. Before we can start the Avastin we need confirmation that my insurance will cover the $5,000 per injection. Anyway, my concern is how well she will be able to handle the Avastin. Looks like some potentially serious side effects. During the past month my wife's condition has been deteriorating fast. She can no longer walk on her own. Her left arm and leg are almost completely papralyzed and her right side is getting weaker daily. She now needs assistance with almost everything (transfer from bed to wheelchair, getting on the toilet, bathing, even rolling over in bed, etc.). She is always extremely tired, some short-term memory loss, losing voice after speaking for a few minutes, some headaches, dizzy spells, and pain in her left leg. She feels she will not be here on earth much longer. Oncologist has not given us a timeline but has basically implied the same. She is really struggling with the fact that she can't take care of her 3 young children anymore. She feels useless. My question is, has anyone had postive results with Avastin? With the shape she is already in, how will her body be able to handle Avastin? Is there a chance that she will get her strength back or would this most likely only give her a couple extra months of being bound to a wheelchair with a new set of side effects to manage?