Folfox

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grammadebbie
grammadebbie Member Posts: 464
edited March 2014 in Colorectal Cancer #1
What is the difference between folfox 4 and folfox 6. I had folfox 4 with oxy a year ago and now I'm reading about folfox 6. Just curious.

Thanks for your help.

Blessings to all,

Debbie (gramma)

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  • Buzzard
    Buzzard Member Posts: 3,043 Member
    #2
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    Unless its simply the amount of cycles
    I am not sure.sorry
  • grammadebbie
    grammadebbie Member Posts: 464
    #3
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    Buzzard said:

    Unless its simply the amount of cycles
    I am not sure.sorry

    ???
    Thanks, I was scheduled for 12 rounds but had to stop at 11 due to severe reaction. Will check it out further and see what I can find out. No biggy just curious.

    Blessing to you,

    Debbie (gramma)
  • patsy1954
    patsy1954 Member Posts: 85
    #4
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    grammadebbie said:

    ???
    Thanks, I was scheduled for 12 rounds but had to stop at 11 due to severe reaction. Will check it out further and see what I can find out. No biggy just curious.

    Blessing to you,

    Debbie (gramma)

    Folfox
    I went on line and couldn't really figure it out either. I am on Folfox6 and have gotten 11 of my 12 treatments (next week #12). I get OXI, Leucovorin, Avastin, and 5FU. Maybe it's the dosage amount?

    Pat
  • PhillieG
    PhillieG Member Posts: 4,866 Member
    #5
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    From the National Cancer Institute
    FOLFOX
    An abbreviation for a chemotherapy combination used to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. It includes the drugs leucovorin calcium (folinic acid), fluorouracil, and oxaliplatin. FOLFOX-4, FOLFOX-6, and FOLFOX-7 are different in the doses of the three drugs and the ways they are given. Also called FOLFOX regimen.

    Hope this clears things up a bit
    -phil
  • Mchapp
    Mchapp Member Posts: 95
    #6
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    PhillieG said:

    From the National Cancer Institute
    FOLFOX
    An abbreviation for a chemotherapy combination used to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. It includes the drugs leucovorin calcium (folinic acid), fluorouracil, and oxaliplatin. FOLFOX-4, FOLFOX-6, and FOLFOX-7 are different in the doses of the three drugs and the ways they are given. Also called FOLFOX regimen.

    Hope this clears things up a bit
    -phil

    Folfox 4
    This is given on the following schedule:
    FOLFOX4
    Adjuvant treatment in patients with colon cancer is recommended for 12 cycles, every 2 weeks. The recommended dose schedule given every two weeks is as follows:
    Day 1: Oxaliplatin 85 mg/m² IV infusion in 250-500 mL D5W and leucovorin 200 mg/m² IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
    Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
    Day 3: unhook iv infusion pump at office or at home (home health RN)
    Day 4: may need an injection of Neulasta to rebuild white blood cells.
  • grammadebbie
    grammadebbie Member Posts: 464
    #7
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    Mchapp said:

    Folfox 4
    This is given on the following schedule:
    FOLFOX4
    Adjuvant treatment in patients with colon cancer is recommended for 12 cycles, every 2 weeks. The recommended dose schedule given every two weeks is as follows:
    Day 1: Oxaliplatin 85 mg/m² IV infusion in 250-500 mL D5W and leucovorin 200 mg/m² IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
    Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
    Day 3: unhook iv infusion pump at office or at home (home health RN)
    Day 4: may need an injection of Neulasta to rebuild white blood cells.

    Thanks
    Very interesting. Appreciate the information. Take care all.

    Blessing to all,

    Debbie (gramma)

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