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What does Her-2/neu negative mean?

Noel's picture
Noel
Posts: 3101
Joined: Apr 2009

I know it was explained to me, but, I forget what it actually means inre to treatment. Does anyone know here? Thanks!

Jeanne D's picture
Jeanne D
Posts: 1867
Joined: Mar 2009

I should know, but, I forget too. lol I think it means whether or not you can metabolize tamoxifen? I don't know.. I need to google it or go thru my oncologist's notes. Hopefully, someone here can tell you to save me time googlinggggggggggg! lol

Moopy23's picture
Moopy23
Posts: 1753
Joined: Jan 2009

Hi, Noel, Herceptin works for cancers that are Her-2/Neu Positive. That's the treatment difference.

tommaseena's picture
tommaseena
Posts: 1771
Joined: Feb 2009

I was at the oncologist office today and the nurse and oncologist were saying that they are now using Herceptin for HER2 negative cancers as well. It has only been happening in the last couple of months because of studies they have done and got approval to use it on all HER2. I haven't researched it personally. I just did and could not find it on the internet so maybe next week when I go I will see if they have any information regarding this.

HER2- means that your gene is not an aggressive breast cancer type like the HER2+ which has an abundant amount of protein on this gene. HER2- does not carry this extra protein which causes aggressive type breast cancer.

I am not saying that aggressive type breast cancers are all HER2+ for there are many type of breast cancers out there.

Hopefully this helps some.
Margo

Kristin N's picture
Kristin N
Posts: 1969
Joined: Mar 2009

I guess I don't understand that either. So, if you are Her2 negative, that is good? And, isn't herceptin a chemo drug? Or, is it one of the hormone therapy drugs? I looked on my pathology report and I am also Her2 negative. I am still in radiation treatments, so, I am not talking yet to my oncologist about what comes next. I wish nothing, but, I know that is probably being unrealistic. Thanks Margo for that info. It helped me to understand better.

tommaseena's picture
tommaseena
Posts: 1771
Joined: Feb 2009

Herceptin is not a chemo drug. It targets the protein that is on the HER2+ gene to kill the protein that caused this type of cancer.

Noel's picture
Noel
Posts: 3101
Joined: Apr 2009

I kind of get it now. lol I will do some more research on the www. You all are so helpful! You are amazing! I just got worried when I saw that on my pathology report and couldn't remember if it was important or not. I am going to blame it on RAD BRAIN! lol

tami90650
Posts: 82
Joined: Mar 2009

so then what does hormone receptive mean?

mimivac's picture
mimivac
Posts: 2147
Joined: Dec 2008

Hormone receptive is when a tumor is receptive to (feeds off of) certain hormones. So an estrogen receptive cancer is one that feeds off of estrogen, or uses it to grow. Tamoxifen acts by blocking breast cancer cells from using estrogen to form and grow. Aromatose inhibtors act by reducing the level of estrogen in the body.

Mimi

Christmas Girl's picture
Christmas Girl
Posts: 3661
Joined: Apr 2009

Good one, Noel! I say, hey - why not?!? :-)

Chemo brain, rad brain, BC brain... It's ALL the same crap!

Kind regards, Susan

dmdudra's picture
dmdudra
Posts: 50
Joined: Apr 2009

Herceptin is for those that are HER2 positive which means that the cancer is due to hormones in your body. it kills the receptor that causes breast cancer. I am HER2 neg.. I was told triple negative.. talk about flunking a test that I wish I could have studied for... darn it anyway.. have a good day

Noel's picture
Noel
Posts: 3101
Joined: Apr 2009

So, HER-2/neu negative is really bad?

cats_toy's picture
cats_toy
Posts: 1463
Joined: Feb 2009

Noel, sorry to go off subject, but I just love your dancing kitty. I want him for my own!
Cat

mimivac's picture
mimivac
Posts: 2147
Joined: Dec 2008

HER-2/neu negative is not bad. In fact, it is usually considered really good. HER-2 positive cancers are generally more aggressive than those that are negative. Now, there is Herceptin to treat HER-2 positives, and it's been a life-saver. If you are negative, you don't have to worry about how to treat the overexpression of the HER-2 gene.

Mimi

Noel's picture
Noel
Posts: 3101
Joined: Apr 2009

Thank you Mimi. I am glad that for the people with HER-2 positive that Herceptin helps them. I know that my oncologist will help me to understand this, but, I won't see him for a few weeks. ( still in radiation ) Thanks again to everyone! I guess the unknown just scared me, but, all of you helped me!

Kristin N's picture
Kristin N
Posts: 1969
Joined: Mar 2009

I am also Her2 negative so this was important to read. So, I guess being negative is better than being positive? Although, I am Er and Pr positive :(

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