My mom was just diagnosed with UPSC this past December. She is a stage IV breast cancer patient that presented with post menapausal bleeding so her onc. ordered an internal ultra sound, and found a polyp and thickening of endometrial lining. He sent us to the obgyn/onc who due to the damage from all of the radiation she has had for the breast mets couldn't do a physical examination. He told us he was 99% sure from the film that she had endometrial cancer and needed all the works removed for staging. After surgery, he informed us that it was definitely cancer and assumed it was from the Tamoxifin she had taken for breast cancer. We had already exhausted all treatment for breast cancer because she didn't want to go through any trials. 6 recurrences over 13 years and lost my father 7 years ago, so she had given up with our last round last May. Pathology report comes back UPSC, histologic grade- high, vascular invasision- positive, and myometrial thickness was 1.4 cm with the cancer invading up to 1.39 cm. He said her lymph nodes were so melded together from radiation that he only got 1 from 1 side. It was neg., but I remember when she had a mastectamy, they took out 29 lymph nodes and only 3 of those were positive. He told us that this cancer is not related to the breast cancer as first thought. We were devastated! Couldn't have radiation because already had high dose to pelvis and abdoman from mets to bone. He said because of all she had already been through, he wanted 6 rounds of chemo, hoped she could make it through 4, but might only get 1. Well the first one nearly did her in. She has gone through chemo several times before, but she is just so weak and tired. When we went in to tell her Dr. he of course didn't want her to give up, but he respected her wishes. He then ordered a PET scan to see if anything else was going on, and that's when we found out the breast cancer is back in 2 new places! So we now have 2 active primary cancers going on at the same time. This was Jan. 8. She has been on Oxycontin slow release and Oxycodone for break through pain for over 3 years due to the mets up and down her spine. She is on a walker since last May's episode. She is only 65 and it breaks my heart to watch her go through this, but she has fought for 13 years. We have now called in Hospice who have added the Fentnyl pain patch to her other meds. I have researched UPSC for 2 months wanting answers to what I'm not really sure. My husband says I'm like a dog with a bone, and just won't give it up. I think all her pain is from the cancer in her bones, but anyone tell me any compications you are having with the uterine cancer. All the stats are so depressing. Also, I'm 37 and wondering what should I worry about. Everything I have read has been in post menapause cases, but 1 lady on here is only 2 years older than me. We have no history in my family of uterine cancers, but we had no history of breast cancer either!