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Management of recurrent or progressive high grade astrocytoma and anaplastic oligodendroglioma

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Type: 
Article
Description: 

Outline of Topic

INTRODUCTION

BENEFIT OF SALVAGE THERAPY

SURGERY
• Gliadel wafer

RADIATION THERAPY
• Brachytherapy
• Stereotactic radiosurgery
• Stereotactic radiotherapy
• Concurrent chemotherapy

CHEMOTHERAPY
• General principles
• The blood brain barrier
• Clinical trial design
• Defining treatment activity in phase II trials
• Phase III testing
• Evaluation of QOL during treatment
• Analysis of phase III trial outcomes
• Single agent chemotherapy
• Temozolomide
• Combination chemotherapy
• Antiangiogenic agents
• Anaplastic oligodendroglioma

SUMMARY AND RECOMMENDATIONS

Source: 
Up to Date Patient Information
Author/Speaker/Performer: 
Tracy Batche, M, MPH
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