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Small Bowel Cancer

2ndtimer's picture
2ndtimer
Posts: 2
Joined: Apr 2007

I'm recovering from small bowel cancer. I have found very little information online. I'd like to hear from anyone who has or had small bowel cancer, or has links to any information. Good luck to all of you.
2ndtimer

Leahi
Posts: 3
Joined: May 2007

Hello .... I have had small cell colorectal cancer twice-initially in 2/03 and then a return of cancer in 2/05 to the outside of the rectal wall. The first time around I had chemo (carbo platin and VP16) and radiation. The second time I had surgery with internal brachy (sp?) radiation, then two sessions of chemo. I don't recall offhand what type of med was used for chemo the second time around but it was drastic enough to instigate a c-diff infection from which I almost died and put me into hospice care for about 6 months. Since it's been coming back every two years, I am really happy that my last colonoscopy (results 2 weeks ago) came back clear. Life is so-so. Have been put on disability primarily for bowel issues--is a constant, unpredictable battle. I am here to chat about that issue, which is the good news. But it's a challenge nonetheless.
Is this of any assistance to you? I wish you luck and a healthy outlook!

Felixthecat
Posts: 37
Joined: Dec 2007

The drug referred to below is only available via the FMF’s Compassionate Use Program so if other treatments are unsuccessful you could contact them and try it. It is a hormone antagonist and quite well tolerated as meds go:

Their website link is:
http://feminist.org/rrights/compassionateuse.asp

2004: Effects of mifepristone on proliferation of human gastric adenocarcinoma cell line SGC-7901 in vitro.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15309708&itool=iconfft&query_hl=20&itool=pubmed_docsum
Mifepristone effectively inhibited the proliferation of PR-positive human gastric adenocarcinoma cell line SGC-7901 in vitro through multiple mechanisms, and may be a beneficial agent against human adenocarcinoma

2004: (Detailed article) Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone
http://www.thymic.org/thypdf/biol/mif2.pdf

2004: Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone
http://www.wjgnet.com/1007-9327/abstract_en.asp?v=10&f=1722
Mifepristone has potent reversal effect on MDR in SGC7901/VCR via inhibiting the function of MRP and P-gp, modulating the expression of Bcl-2 and Bax proteins, and enhancing the sensitivity to anticancer agent VCR

2004: Inhibitory effects of mifepristone on the growth of human gastric cancer cell line MKN-45 in vitro and in vivo.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15669177&itool=iconabstr&query_hl=20&itool=pubmed_docsum
Mifepristone exerts significant growth inhibitory effects on PR-positive human MKN-45 gastric cancer cells via multiple mechanisms, and may be a beneficial agent against the tumor.

2004: Effects of mifepristone on invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15188494&dopt=
• “Mifepristone can effectively inhibit the invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo through inhibition of heterotypic adhesion to basement membrane, cell migration and angiogenesis.”

2003: Glucocorticoid Cotreatment Induces Apoptosis Resistance toward Cancer Therapy in Carcinomas1
http://cancerres.aacrjournals.org/cgi/content/full/63/12/3112

GCs are widely used in high doses in the therapy of leukemias and lymphomas and are also used as antiemetics or preservatives for normal cells during chemotherapy of solid tumors. In addition, GCs are among the most widely used anti-inflammatory drugs. In this study, we have shown that application of GCs renders certain tumors resistant or less susceptible to apoptosis after cancer therapy. This finding urges to carefully reconsider the widespread use of GCs in almost all treatment protocols for patients with solid cancers. In the clinical setting of cancer therapy, e.g., in antiemetic regimens, corticosteroids are usually given transiently to suppress acute side effects of cancer therapy. Although our experiments did not mimic precisely the clinical situation because we administered DEX daily to achieve steady-state levels, short-term exposure to DEX may nevertheless be sufficient to abrogate or diminish the efficacy of concomitant chemotherapy in cancer patients in vivo. This is suggested by our experiments where DEX was found to down-regulate basal and cisplatin-induced expression of apoptosis effectors within 24 h in vitro. Also, endogenous levels of GCs and those existing as a consequence of administered hormones may render solid tumors less susceptible to apoptosis after cancer therapy. The administration of steroid/receptor agonists such as RU486 might be beneficial before chemotherapy and radiotherapy to enhance cell death of solid tumor cells

rschnat
Posts: 1
Joined: Jun 2007

2ndtimer: My mother was diagnosed with small bowel cancer in February. It is stage 4 so they were unable to do the Whipple procedure. The surgeon did a bypass around the tumor so mom could eat. She has had 4 rounds of chemo but is experiencing quite a bit of pain. My family, like you, is frustrated that there is not more information on this type of cancer...I guess it is very rare. I hope your recovery is going well.

Rob

pmppals's picture
pmppals
Posts: 5
Joined: Jun 2002

For information about treatment of, and recuperation from, rare cancers affecting the digestive system, visit http://www.pmppals.org
This site includes a wide variety of resources, including specialists, surgical treatments, chemotherapies, gastrectomies, ostomies and more!

ladydc
Posts: 2
Joined: Jul 2007

I am a small bowel cancer survivor (adenocarcinoma) of 6 years. I was 36 when I was diagnosed and was very lucky that it was diagnosed early. It had only affected 1 lymph node. I had a small bowel resection with the tumor and 1 foot of my small bowel removed. I took 5FU and Leuvorcin (? on spelling) for 6 months. Life is good and I feel well. God has blessed me greatly.

I found it very frustrating that there is so little info on small bowel cancer. My GI almost didn't do a small bowel follow through because the cancer is so rare and very uncommon for a 36 year old.

I wish you the best.

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