Experience with xeloda and erbitux?

impactzone
impactzone Member Posts: 551 Member
edited March 2014 in Colorectal Cancer #1
I posted my dilemna earlier. I so appreciate your suggestions. If I do start chemo next week it will be xeloda, oxaliplatin and erbitux. Can anyone tell me their experience with these drugs? I am aware of the side effects of oxa, but how about the other two? Can you work with them? Nausea, mouth sores, hand and foot issues?
Thanks
Chip Fenenga

Comments

  • AuthorUnknown
    AuthorUnknown Member Posts: 1,537 Member
    My mother was on Xeloda. She could not tolerate it at all. Her liver functions went up greatly, she was getting increasingly weak, and then she got pneumonia as a result of immune system jeopardised by Xeloda. I had to stop it for her. Other people on this board took it without a problem. So, I guess it is different for everyone. Per my mother's oncologist, Xeloda is very damaging to the liver. Hope it helps.

    Best wishes with whatever you decide to do.

    God Bless, Eleonora
  • dee42
    dee42 Member Posts: 23
    My mom was on Xeloda (pills) last year and could only complete 75% of the treatment because of liver levels getting out of control. Other than it affecting her liver, the only other noteable side effect was extreme fatigue. She decided to stop the treatment after she got an eye infection and soon after came down w/bronchitis. She is currently on Eloxatin, 5FU, and Leucovorin. So far, so good, except for bad mouth sores and mild nausea.

    Best wishes and be encouraged!
  • shmurciakova
    shmurciakova Member Posts: 906 Member
    I had Xeloda with Camptosar at the age of 34. I did not have any problems with my liver functions or immune system. The bad thing about it in my opinion was the hand/foot syndrome. I am a forest ranger and continued to work during my chemo. The Xeloda made it very difficult. I had to stop backpacking because my feet could not tolerate the weight. I got these really nasty blisters and my toenails were disgusting to say the least. I was able to continue on "day hikes" but it really put a damper on my lifestyle despite the convenience of the "pill". Previously, after my colon resection I was on plain old 5-FU IV. It was more inconvenient but did not cause the hand/foot issue.
    If you are an active person and you run/walk/hike and this is a big part of your life, then I would not recommend Xeloda. However, if you do not take part in activities that require abuse of the feet, you will probably be just fine.
    As I stated before, I would tend to lean towards the surgery first option - but that is your decision.
    Cheers,
    Susan H.
  • Betsydoglover
    Betsydoglover Member Posts: 1,248 Member
    Hi Chip -

    I was on Xeloda/oxaliplatin/Avastin. I had NO problem with blood counts or liver / kidney function. After 4 treatments of Xeloda (4000mg/day) I had very slight peeling of skin on my feet - my onc cut the dose back to 3000mg/day and that solved the problem (and also resolved the mild, episodic diarrhea I experienced from the Xeloda).

    Hope this helps,
    Betsy
  • LOUSWIFT
    LOUSWIFT Member Posts: 371 Member
    I took xeloda for six weeks during radiation 2000mg - no problems at all but post surgery the dose went to 10,000 mg and I developed severe hand and foot syndrome and depressed platelett and white blood cell counts. It was miserable and 3 months later still experiencing some side-effects. I did work (Computer Operator). I had to wear gloves and socks 24/7 for the bag balm needed but there was no way I could have worked if I didn't sit in a chair most of the time. Almost impossible to walk and pain medications only somewhat effective. Hopefully it worked I will find out next week. I found out thanks to this site that vitamin B6 will help with the hands but you need to start and stay on the vitamin throughout treatment.
  • oneagleswings
    oneagleswings Member Posts: 425 Member
    My husband is on xeloda and oxaliplatin and comared to 5FU/Irinotecan(folfiri) is has been a cake walk..only mild tingles in hands and feet..no nausea, fatigue etc..the only down side is the exttremely low platelets that keep him missing doses.
    Bev