Mar 10, 2005 - 1:10 am
Hi, anyone out there have or heard of dx Anaplastic PXA (Pleomorphic Xanthoastrocytoma). My husband was diagnosed 7/01 (original dx was just PXA) right temporal lobe. Surgery followed by monitoring w/MRI. Recurrence 10/01, sugery showed it more aggressive, so dx "anaplastic" PXA. Had 4 wks hyprefractionated rad with Temodar, then proton boost at MGH, Boston. Stable during maint. chemo of Tem,Accutane,celebrex for about 18 mos., then recurrence a few mos. after stopping in right parietal lobe on dura (10/03). Surgery ...same dx. MRI after surgery showed drop mets on spine...inoperable. Did CPT-11/Temodar, then spine rad (focused). Then vp-16, spine stable, but recurrence in parietal lobe dura 1/05, surgery, now following it with focused proton beam rad tomorrow. Not sure what the next step in terms of chemo should be. Rad seems to be effective for this tumor. What has anyone else's experience with this been?