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FOLFOX4 regimen for Stage 3, T 2

olafsky
Posts: 1
Joined: Jun 2004

Should FOLFOX4 regimen be used for treatment of stage 3, T 2 colon cancer after resection with one affected lymph node?

nanuk's picture
nanuk
Posts: 1363
Joined: Dec 2003

dunno, but I was stage 3, T2 rectal cancer, and no
node involvement..now have mets to lungs 3+ years later. Some kind of adjuvant chemotherapy/radiation
is probably indicated; if you are not confident in your Dr's decision, get a 2nd opinion. Bud

taraHK
Posts: 1961
Joined: Aug 2003

Hi. I was stage 3 (T3, N1, MO - one lymph node affected) rectal cancer. I had presurgical chemoradiation (recommended for many rectal cancers) then had chemo after surgery using 'traditional' (5FU and leucovorin). About 2/3 thro' my chemo, some research was coming coming out regarding the value of FOLFAX (ie the addition of oxaliplatin) for people in circumstances similar to mine. My oncologist and I decided not to switch - for several reasons. In my opinion, your oncologist or physician should be able to provide you with up-to-date information regarding the relative advantages and disadvantages of these (and other) treatments, for individuals in your situation. I wish you all the best with your treatment.
Tara

jsabol's picture
jsabol
Posts: 1156
Joined: Dec 2003

Hi, I'm also stage III, 1 affected node, no penetration of bowel wall. My onc group has also prescribed the "traditional" 5FU and leuco. I do keep inquiring about the virtues of more aggressive chemo, but my oncs (and a second opinion) felt that I was early enough (small polyp, node was microscopically positive, didn't reveal itself on CT scan) that more aggressive chemo was not indicated. Sure hope they are right! If in doubt, second opinions may help. Good luck, Judy

JenniV
Posts: 10
Joined: May 2004

My mother is currently being treated post-op with Folfox as well. She is Stage 3 with multiple lymph nodes positive (all microscopic). From what I have read, this is the top of the line treatment for colorectal cancer. Her Dr. told her it was an agressive treatment. My thoughts are, go with the most agressive treatment you can! Fight the beast with everything.Though it is a newer treatment regimine, it appears to be the best option right now! Good luck!

Fitlisa
Posts: 99
Joined: May 2004

I am also Stage III, 14 of 32 nodes positive - had a bowel resection 5 weeks ago and started Folfox 1 week later (I have now completed 4 of 20 treatments).

My onc determined that due to my age (42) and the # of nodes effected, this was by far the best choice for me. He is, as am I tho, very aggressive in beating this thing. Its not been easy, but its not been as hard as I had anticipated either. Everybody is different and every body is different. I would definitely be discussing this with your onc tho.

Best of luck,

Lisa

Kanort's picture
Kanort
Posts: 1275
Joined: Jan 2004

Hi,

I am stage 3, 3 out of 31 nodes positive,and no bowel involvement. My CEA levels prior to surgery were normal, and I had negative CAT and PET scans as well.

I began Folfox 4 in November and had my last treatment on Friday. We, too, went with the more agggresive approach.

There are other patients in the infusion room with similar diagnosis as mine who are receiving the traditional 5Fu and leuv. I'm not sure why our treatments are different, but my oncologist knew I wanted the lastest and most aggresive treatment allowed.

Best wishes to you as you make your decision.

Kay

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