Feb 20, 2004 - 11:11 am
My husband, 59, was diagnosed with GBM IV in the left temporal lobe Sept. '03 and had resection Oct. 1st. Neurosurgeon felt he got the whole tumor. 6 weeks of radiation followed, ending Dec. 16. My husband had a post-radiation MRI in Jan., and it showed no tumor. Neurosurgeon and neurooncologist were very happy with it. Husband had one 5 day round of Temodar during radiation, and then it's being repeated every 28 days. The first 3 rounds of Temodar went pretty easily with the only complaint being constipation and some stomach pain, which were managed by diet and supplements. However, this fourth round has been different. He's having extreme anxiety (he started having some anxiety 2 1/2 weeks following surgery, but this is much, much, much worse), crying spells (something he had at one point in the radiation but it disappeared with an increase in Decadron), loss of appetite, feels really sick, and has had several episodes of double vision (not a constant problem). Since Temodar is quite often used, I was wondering if any of you had had side effects from it or know of people who did. I'm a bit baffled because the first three rounds weren't bad. It's been 4 days since his last dose and no improvement. I have a call in to the doctor. I hate bothering him but I'm in unchartered waters and don't know if something should be done or if this will pass.
I would appreciate any thoughts you might have.